Research Papers: General

Relationship of oscillating and average components of laser Doppler flowmetry signal

[+] Author Affiliations
Irina Mizeva, Peter Frick, Sergey Podtaev

Institute of Continuous Media Mechanics, ak Koroleva 1, Perm 614013, Russia

J. Biomed. Opt. 21(8), 085002 (Aug 22, 2016). doi:10.1117/1.JBO.21.8.085002
History: Received February 19, 2016; Accepted July 18, 2016
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Abstract.  Signals from laser Doppler flowmeters widely used in intravital studies of skin blood flow include, along with a slowly varying average component, an oscillating part. However, in most clinical studies, pulsations are usually smoothed by data preprocessing and only the mean blood flow is analyzed. To reveal the relationship between average and oscillating perfusion components measured by a laser Doppler flowmeter, we examined the microvascular response to the contralateral cold pressor test recorded at two different sites of the hand: dorsal part of the arm and finger pad. Such a protocol makes it possible to provide a wide range of perfusion. The average perfusion always decreases during cooling, while the oscillating component demonstrates a differently directed response. The wavelet analysis of laser Doppler flowmetry (LDF) signals shows that the pulsatile component is nonlinearly related to the average perfusion. Under low perfusion, the amplitude of pulsations is proportional to its mean value, but, as perfusion increases, the amplitude of pulsations becomes lower. The type of response is defined by the basal perfusion and the degree of vasoconstriction caused by cooling. Interpretation of the results is complicated by the nonlinear transfer function of the LDF device, the contribution of which is studied using artificial examples.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Irina Mizeva ; Peter Frick and Sergey Podtaev
"Relationship of oscillating and average components of laser Doppler flowmetry signal", J. Biomed. Opt. 21(8), 085002 (Aug 22, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.8.085002


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