Research Papers: General

Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules

[+] Author Affiliations
Kazumasa Ariyasu, Mitsuhiro Terakawa

Keio University, Department of Electronics and Electrical Engineering, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan

Keio University, School of Integrated Design Engineering, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan

Atsuhiro Ishii, Taiga Umemoto

Keio University, School of Integrated Design Engineering, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan

J. Biomed. Opt. 21(8), 085003 (Aug 23, 2016). doi:10.1117/1.JBO.21.8.085003
History: Received June 21, 2016; Accepted August 9, 2016
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Abstract.  The controlled release of encapsulated molecules from a microcapsule is a promising method of targeted drug delivery. Laser-triggered methods for the release of encapsulated molecules have the advantage of spatial and temporal controllability. In this study, we demonstrated the release of encapsulated molecules from biodegradable polymer-based microcapsules using near-infrared femtosecond laser pulses. The polylactic-co-glycolic acid microcapsules encapsulating fluorescein isothiocyanate-dextran molecules were fabricated using a dual-coaxial nozzle system. Irradiation of femtosecond laser pulses enhanced the release of the molecules from the microcapsules, which was accompanied by a decrease in the residual ratio of the microcapsules. The laser-induced modification of the surface of the shell of the microcapsules indicated the potential for sustained release as well as burst release.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Kazumasa Ariyasu ; Atsuhiro Ishii ; Taiga Umemoto and Mitsuhiro Terakawa
"Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules", J. Biomed. Opt. 21(8), 085003 (Aug 23, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.8.085003


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