Research Papers: General

Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes

[+] Author Affiliations
Lixin Dong, Daniel Irwin, Yu Shang, Chong Huang, Guoqiang Yu

University of Kentucky College of Engineering, Department of Biomedical Engineering, 143 Graham Avenue, Lexington, Kentucky 40506, United States

Mahesh Kudrimoti, Sameera Kumar, Ellis L. Johnson

University of Kentucky College of Medicine, Department of Radiation Medicine, 800 Rose Street, Lexington, Kentucky 40536, United States

Li Chen, Brent J. Shelton

University of Kentucky, Biostatistics and Bioinformatics Shared Resource Facility, Markey Cancer Center, Lexington, 800 Rose Street, Kentucky 40536, United States

University of Kentucky College of Public Health, Department of Biostatistics, Lexington, 111 Washington Avenue, Kentucky 40536, United States

Scott D. Stevens

University of Kentucky College of Medicine, Department of Radiology, 800 Rose Street, Lexington, Kentucky 40536, United States

J. Biomed. Opt. 21(8), 085004 (Aug 26, 2016). doi:10.1117/1.JBO.21.8.085004
History: Received June 11, 2016; Accepted August 8, 2016
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Abstract.  This study used a hybrid near-infrared diffuse optical instrument to monitor tumor hemodynamic responses to chemoradiation therapy for early prediction of treatment outcomes in patients with head and neck cancer. Forty-seven patients were measured once per week to evaluate the hemodynamic status of clinically involved cervical lymph nodes as surrogates for the primary tumor response. Patients were classified into two groups: complete response (CR) (n=29) and incomplete response (IR) (n=18). Tumor hemodynamic responses were found to be associated with clinical outcomes (CR/IR), wherein the associations differed depending on human papillomavirus (HPV-16) status. In HPV-16 positive patients, significantly lower levels in tumor oxygenated hemoglobin concentration ([HbO2]) at weeks 1 to 3, total hemoglobin concentration at week 3, and blood oxygen saturation (StO2) at week 3 were found in the IR group. In HPV-16 negative patients, significantly higher levels in tumor blood flow index and reduced scattering coefficient (μs) at week 3 were observed in the IR group. These hemodynamic parameters exhibited significantly high accuracy for early prediction of clinical outcomes, within the first three weeks of therapy, with the areas under the receiver operating characteristic curves (AUCs) ranging from 0.83 to 0.96.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Lixin Dong ; Mahesh Kudrimoti ; Daniel Irwin ; Li Chen ; Sameera Kumar, et al.
"Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes", J. Biomed. Opt. 21(8), 085004 (Aug 26, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.8.085004


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