Research Papers: General

Use of a micro- to nanochannel for the characterization of surface-enhanced Raman spectroscopy signals from unique functionalized nanoparticles

[+] Author Affiliations
Brian M. Walton

Texas A&M University, Department of Biomedical Engineering, 101 Bizzell Street, College Station, Texas 77843, United States

Po-Jung Huang

Texas A&M University, Department of Material Science and Engineering, 575 Ross Street, College Station, Texas 77843, United States

Jun Kameoka

Texas A&M University, Department of Electrical and Computer Engineering, 188 Bizzel Street, College Station, Texas 77843, United States

Gerard L. Cote

Texas A&M University, Department of Biomedical Engineering, 101 Bizzell Street, College Station, Texas 77843, United States

Texas A&M University, Texas A&M Engineering Experiment Station Center for Remote Health Technologies and Systems, Department of Biomedical Engineering, 101 Bizzell Street, College Station, Texas 77843, United States

J. Biomed. Opt. 21(8), 085006 (Aug 26, 2016). doi:10.1117/1.JBO.21.8.085006
History: Received April 14, 2016; Accepted August 10, 2016
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Abstract.  A micro- to nanochannel nanoparticle aggregating device that does not require any input energy to organize the particles to a specific location, i.e., no pumps, plugs, heat, or magnets, has been designed and used to characterize the surface-enhanced Raman spectroscopy (SERS) signal from four unique functionalized nanoparticles (gold, silver-gold nanocages, silver nanocubes, and silica-gold nanoshells). The SERS signal was assessed in terms of the peak signal strength from the four different Raman reporter functionalized nanoparticles to determine which nanoparticle had better utility in the channel to provide the most robust platform for a future biological analyte detection device. The innovation used to fabricate the micro- to nanochannel device is described; the TEM images of the nanoparticles are shown; the absorption data for the nanoparticles are given; and the spectral data for the Raman reporter, mercaptobenzoic acid (MBA), are depicted. In the micro- to nanochannel described in this work, 5  μl of 22.3  μM MBA functionalized silver nanocubes were determined to have the strongest SERS enhancement.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Brian M. Walton ; Po-Jung Huang ; Jun Kameoka and Gerard L. Cote
"Use of a micro- to nanochannel for the characterization of surface-enhanced Raman spectroscopy signals from unique functionalized nanoparticles", J. Biomed. Opt. 21(8), 085006 (Aug 26, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.8.085006


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