Special Section on Adaptive Optics and Wavefront Control for Biological Systems

Hybridized wavefront shaping for high-speed, high-efficiency focusing through dynamic diffusive media

[+] Author Affiliations
Ashton S. Hemphill, Jian Wei Tay, Lihong V. Wang

Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, Saint Louis, Missouri 63130, United States

J. Biomed. Opt. 21(12), 121502 (Sep 14, 2016). doi:10.1117/1.JBO.21.12.121502
History: Received March 18, 2016; Accepted May 17, 2016
Text Size: A A A

Abstract.  One of the prime limiting factors of optical imaging in biological applications is the diffusion of light by tissue, which prevents focusing at depths greater than the optical diffusion limit (typically 1  mm). To overcome this challenge, wavefront shaping techniques that use a spatial light modulator (SLM) to correct the phase of the incident wavefront have recently been developed. These techniques are able to focus light through scattering media beyond the optical diffusion limit. However, the low speeds of typically used liquid crystal SLMs limit the focusing speed. Here, we present a method using a digital micromirror device (DMD) and an electro-optic modulator (EOM) to measure the scattering-induced aberrations, and using a liquid crystal SLM to apply the correction to the illuminating wavefront. By combining phase modulation from an EOM with the DMD’s ability to provide selective illumination, we exploit the DMD’s higher refresh rate for phase measurement. We achieved focusing through scattering media in less than 8 ms, which is sufficiently short for certain in vivo applications, as it is comparable to the speckle correlation time of living tissue.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Ashton S. Hemphill ; Jian Wei Tay and Lihong V. Wang
"Hybridized wavefront shaping for high-speed, high-efficiency focusing through dynamic diffusive media", J. Biomed. Opt. 21(12), 121502 (Sep 14, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.12.121502


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.