Research Papers: Sensing

In vivo characterization of colorectal metastases in human liver using diffuse reflectance spectroscopy: toward guidance in oncological procedures

[+] Author Affiliations
Jarich W. Spliethoff, Lisanne L. de Boer, Koert Kuhlmann

Netherlands Cancer Institute, Department of Surgery, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands

Mark A. J. Meier, Warner Prevoo

Netherlands Cancer Institute, Department of Radiology, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands

Jeroen de Jong

Netherlands Cancer Institute, Department of Pathology, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands

Torre M. Bydlon, Benno H. W. Hendriks

Philips Research, Department In-body Systems, High Tech Campus 34, 5656AE Eindhoven, The Netherlands

Henricus J. C. M. Sterenborg

Academic Medical Center, Department of Biomedical Engineering and Physics, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands

Theo J. M. Ruers

Netherlands Cancer Institute, Department of Surgery, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands

University of Twente, MIRA Institute, Drienerlolaan 5, Zuidhorst ZH116, 7522 NB Enschede, The Netherlands

J. Biomed. Opt. 21(9), 097004 (Sep 16, 2016). doi:10.1117/1.JBO.21.9.097004
History: Received July 8, 2016; Accepted August 30, 2016
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Abstract.  There is a strong need to develop clinical instruments that can perform rapid tissue assessment at the tip of smart clinical instruments for a variety of oncological applications. This study presents the first in vivo real-time tissue characterization during 24 liver biopsy procedures using diffuse reflectance (DR) spectroscopy at the tip of a core biopsy needle with integrated optical fibers. DR measurements were performed along each needle path, followed by biopsy of the target lesion using the same needle. Interventional imaging was coregistered with the DR spectra. Pathology results were compared with the DR spectroscopy data at the final measurement position. Bile was the primary discriminator between normal liver tissue and tumor tissue. Relative differences in bile content matched with the tissue diagnosis based on histopathological analysis in all 24 clinical cases. Continuous DR measurements during needle insertion in three patients showed that the method can also be applied for biopsy guidance or tumor recognition during surgery. This study provides an important validation step for DR spectroscopy-based tissue characterization in the liver. Given the feasibility of the outlined approach, it is also conceivable to make integrated fiber-optic tools for other clinical procedures that rely on accurate instrument positioning.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Jarich W. Spliethoff ; Lisanne L. de Boer ; Mark A. J. Meier ; Warner Prevoo ; Jeroen de Jong, et al.
"In vivo characterization of colorectal metastases in human liver using diffuse reflectance spectroscopy: toward guidance in oncological procedures", J. Biomed. Opt. 21(9), 097004 (Sep 16, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.9.097004


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