JBO Letters

Quantifying tissue viscoelasticity using optical coherence elastography and the Rayleigh wave model

[+] Author Affiliations
Zhaolong Han, Manmohan Singh, Chih-Hao Liu, Achuth Nair, Raksha Raghunathan, Chen Wu, Jiasong Li

University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States

Salavat R. Aglyamov

University of Texas at Austin, Department of Biomedical Engineering, 107 West Dean Keeton Street, Stop C0800, Austin, Texas 78712, United States

Kirill V. Larin

University of Houston, Department of Biomedical Engineering, 3605 Cullen Boulevard, Houston, Texas 77204, United States

Tomsk State University, Interdisciplinary Laboratory of Biophotonics, 36 Lenin Avenue, Tomsk 634050, Russia

Baylor College of Medicine, Molecular Physiology and Biophysics, One Baylor Plaza, Houston, Texas 77030, United States

J. Biomed. Opt. 21(9), 090504 (Sep 20, 2016). doi:10.1117/1.JBO.21.9.090504
History: Received June 14, 2016; Accepted August 30, 2016
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Abstract.  This study demonstrates the feasibility of using the Rayleigh wave model (RWM) in combination with optical coherence elastography (OCE) technique to assess the viscoelasticity of soft tissues. Dispersion curves calculated from the spectral decomposition of OCE-measured air-pulse induced elastic waves were used to quantify the viscoelasticity of samples using the RWM. Validation studies were first conducted on 10% gelatin phantoms with different concentrations of oil. The results showed that the oil increased the viscosity of the gelatin phantom samples. This method was then used to quantify the viscoelasticity of chicken liver. The Young’s modulus of the chicken liver tissues was estimated as E=2.04±0.88  kPa with a shear viscosity η=1.20±0.13  Pas. The analytical solution of the RWM correlated very well with the OCE-measured phased velocities (R2=0.96±0.04). The results show that the combination of the RWM and OCE is a promising method for noninvasively quantifying the biomechanical properties of soft tissues and may be a useful tool for detecting disease.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Zhaolong Han ; Manmohan Singh ; Salavat R. Aglyamov ; Chih-Hao Liu ; Achuth Nair, et al.
"Quantifying tissue viscoelasticity using optical coherence elastography and the Rayleigh wave model", J. Biomed. Opt. 21(9), 090504 (Sep 20, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.9.090504


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