Special Section on Clinical Near-Infrared Spectroscopy and Imaging

Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography

[+] Author Affiliations
Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Brian W. Pogue, Keith D. Paulsen

Dartmouth College, Thayer School of Engineering, 14 Engineering Drive, Hanover, New Hampshire 03755, United States

Linxi Shi

Georgia Institute of Technology, School of Mechanical Engineering, 801 Ferst Drive, Atlanta, Georgia 30332, United States

Srinivasan Vedantham, Andrew Karellas

University of Massachusetts Medical School, Department of Radiology, 55 Lake Avenue North, Worcester, Massachusetts 01655, United States

Steven P. Poplack

Washington University School of Medicine, Mallinckrodt Institute of Radiology, 4921 Parkview Place, St. Louis, Missouri 63110, United States

J. Biomed. Opt. 21(9), 091316 (Sep 27, 2016). doi:10.1117/1.JBO.21.9.091316
History: Received March 6, 2016; Accepted August 30, 2016
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Abstract.  Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast tomosynthesis (DBT). Image data were analyzed from 27 women who underwent four IRB approved NIRST/DBT exams that included fully and mildly compressed breast acquisitions in two projections—craniocaudal (CC) and mediolateral-oblique (MLO)—and generated four data sets per patient (full and moderate compression in CC and MLO views). Breast density was correlated with HbT (r=0.64, p=0.001), water (r=0.62, p=0.003), and lipid concentrations (r=0.74, p<0.001), but not oxygen saturation. CC and MLO views were correlated for individual subjects and demonstrated no statistically significant differences in grouped analysis. Comparison of compressed and uncompressed imaging demonstrated a significant decrease in oxygen saturation under compression (58% versus 50%, p=0.04). Mammographic breast density categorization was correlated with measured optically derived properties.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Kelly E. Michaelsen ; Venkataramanan Krishnaswamy ; Linxi Shi ; Srinivasan Vedantham ; Andrew Karellas, et al.
"Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography", J. Biomed. Opt. 21(9), 091316 (Sep 27, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.9.091316


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