Special Series on Translational Biophotonics

Tethered capsule endomicroscopy: from bench to bedside at a primary care practice

[+] Author Affiliations
Michalina J. Gora

Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, United States

Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, United States

Strasbourg University, CNRS, ICube Laboratory, 1 Place de l’Hopital, Strasbourg 67091, France

Leigh H. Simmons

Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, United States

Massachusetts General Hospital, Division of General Internal Medicine, 55 Fruit Street, Boston, Massachusetts 02114, United States

Lucille Quénéhervé

Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, United States

Institut des Maladies de l’Appareil Digestif, CHU Nantes, Hôtel Dieu, place Alexis Ricordeau, Nantes 44000, France

Catriona N. Grant, Robert W. Carruth, Weina Lu, Aubrey Tiernan, Amna Soomro

Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, United States

Jing Dong, Mireille Rosenberg

Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, United States

Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, United States

Beth Walker-Corkery, Joshua P. Metlay

Massachusetts General Hospital, Division of General Internal Medicine, 55 Fruit Street, Boston, Massachusetts 02114, United States

Guillermo J. Tearney

Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, United States

Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, United States

Massachusetts General Hospital, Department of Pathology, 55 Fruit Street, Boston, Massachusetts 02114, United States

Harvard-MIT Division of Health Sciences Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

J. Biomed. Opt. 21(10), 104001 (Sep 30, 2016). doi:10.1117/1.JBO.21.10.104001
History: Received June 6, 2016; Accepted September 12, 2016
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Abstract.  Due to the relatively high cost and inconvenience of upper endoscopic biopsy and the rising incidence of esophageal adenocarcinoma, there is currently a need for an improved method for screening for Barrett’s esophagus. Ideally, such a test would be applied in the primary care setting and patients referred to endoscopy if the result is suspicious for Barrett’s. Tethered capsule endomicroscopy (TCE) is a recently developed technology that rapidly acquires microscopic images of the entire esophagus in unsedated subjects. Here, we present our first experience with clinical translation and feasibility of TCE in a primary care practice. The acceptance of the TCE device by the primary care clinical staff and patients shows the potential of this device to be useful as a screening tool for a broader population.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Michalina J. Gora ; Leigh H. Simmons ; Lucille Quénéhervé ; Catriona N. Grant ; Robert W. Carruth, et al.
"Tethered capsule endomicroscopy: from bench to bedside at a primary care practice", J. Biomed. Opt. 21(10), 104001 (Sep 30, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.10.104001


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Review: Surveillance of patients with Barrett oesophagus. Best Pract Res Clin Gastroenterol 2016;30(6):901-912.
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