Research Papers: Therapeutic

Isolated and combined effects of photobiomodulation therapy, topical nonsteroidal anti-inflammatory drugs, and physical activity in the treatment of osteoarthritis induced by papain

[+] Author Affiliations
Shaiane Silva Tomazoni, Rodney Capp Pallotta, Simone Teixeira, Patricia de Almeida

University of São Paulo (USP), Laboratory of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Institute of Biomedical Sciences, Avenida Lineu Prestes 1524, Butantan, São Paulo 05508-900, Brazil

Ernesto Cesar Pinto Leal-Junior

Nove de Julho University (UNINOVE), Post Graduate Program in Biophotonics Applied to Health Sciences and Post Graduate Program in Rehabilitation Sciences, Rua Vergueiro 235, São Paulo 01504-001, Brazil

Lúcio Frigo

Cruzeiro do Sul University (UNICSUL), Biological Sciences and Health Center, Avenida Doutor Ussiel Cirilo 225, São Paulo 08060-070, Brazil

Jan Magnus Bjordal

University of Bergen, Department of Global Public Health, Physiotherapy Research Group, PO Box 7804, Bergen, Norway

Rodrigo Álvaro Brandão Lopes-Martins

Universidade de Mogi das Cruzes (UMC), Biomedical Engineering Research and Post-Graduate Center, Avenida Doutor Cândido Xavier de Almeida e Souza, 200 Mogi das Cruzes, São Paulo 08780-911, Brazil

Universidade Camilo Castelo Branco, Faculty of Medicine, Avenida dos Expedicionários Brasileiros, 781, Fernandópolis, São Paulo 15600-000, Brazil

J. Biomed. Opt. 21(10), 108001 (Oct 18, 2016). doi:10.1117/1.JBO.21.10.108001
History: Received April 13, 2016; Accepted September 19, 2016
Text Size: A A A

Abstract.  Osteoarthritis (OA) is a chronic inflammatory disease and is characterized as a degenerative process. This study aimed to evaluate and compare the effects of a topical nonsteroidal anti-inflammatory drug (NSAID), physical activity, and photobiomodulation therapy (PBMT) applied alone and/or in combination between them in an experimental model of knee OA. OA was induced by injection of papain in the knees of rats. After 21 days, the animals started to be treated with the above treatment. Histological analysis shows that the experimental model of OA induction causes morphological changes consistent with the disease, and among treatments, the PBMT is the most effective for reducing these changes. Moreover, the results demonstrate that PBMT and NSAID reduce the total number of cells in the inflammatory infiltrate (p<0.05) and PBMT was the most effective for reducing the activity of myeloperoxidase (p<0.05). Finally, we observed that both NSAID and PBMT were effective for reducing the gene expression of MMP-3 (p<0.05), but in relation to the gene expression of MMP-13, PBMT was the most effective treatment (p<0.05). The results of this study indicate that PBMT is the most effective therapy in stopping disease progression, and improving inflammatory conditions observed in OA.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Shaiane Silva Tomazoni ; Ernesto Cesar Pinto Leal-Junior ; Lúcio Frigo ; Rodney Capp Pallotta ; Simone Teixeira, et al.
"Isolated and combined effects of photobiomodulation therapy, topical nonsteroidal anti-inflammatory drugs, and physical activity in the treatment of osteoarthritis induced by papain", J. Biomed. Opt. 21(10), 108001 (Oct 18, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.10.108001


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement


 

  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.