Special Section on Photoacoustic Imaging and Sensing

Handheld optical-resolution photoacoustic microscopy

[+] Author Affiliations
Li Lin, Pengfei Zhang, Junhui Shi, Lei Li, Junjie Yao, Lidai Wang, Lihong V. Wang

Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, St. Louis, Missouri 63130, United States

Song Xu, Jun Zou

Texas A&M University, Institute for Solid State Electronics, Electrical Engineering Department, 400 Bizzell Street, College Station, Texas 77840, United States

J. Biomed. Opt. 22(4), 041002 (Oct 24, 2016). doi:10.1117/1.JBO.22.4.041002
History: Received April 21, 2016; Accepted June 9, 2016
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Abstract.  Optical-resolution photoacoustic microscopy (OR-PAM) offers label-free in vivo imaging with high spatial resolution by acoustically detecting optical absorption contrasts via the photoacoustic effect. We developed a compact handheld OR-PAM probe for fast photoacoustic imaging. Different from benchtop microscopes, the handheld probe provides flexibility in imaging various anatomical sites. Resembling a cup in size, the probe uses a two-axis water-immersible microelectromechanical system mirror to scan both the illuminating optical beam and resultant acoustic beam. The system performance was tested in vivo by imaging the capillary bed in a mouse ear and both the capillary bed and a mole on a human volunteer.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Li Lin ; Pengfei Zhang ; Song Xu ; Junhui Shi ; Lei Li, et al.
"Handheld optical-resolution photoacoustic microscopy", J. Biomed. Opt. 22(4), 041002 (Oct 24, 2016). ; http://dx.doi.org/10.1117/1.JBO.22.4.041002


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