Special Section on Photoacoustic Imaging and Sensing

Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo

[+] Author Affiliations
Terence T. W. Wong, Yong Zhou, Alejandro Garcia-Uribe, Lei Li, Konstantin Maslov, Li Lin, Lihong V. Wang

Washington University in St. Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, One Brookings Drive, Saint Louis, Missouri 63130, United States

J. Biomed. Opt. 22(4), 041003 (Oct 24, 2016). doi:10.1117/1.JBO.22.4.041003
History: Received August 24, 2016; Accepted October 10, 2016
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Abstract.  While lasers have been commonly used as illumination sources in photoacoustic (PA) imaging, their high purchase and maintenance costs, as well as their bulkiness, have hindered the rapid clinical dissemination of PA imaging. With this in mind, we explore an alternative illumination source for PA tomography—a xenon flash lamp with high pulse energy and a microsecond pulse width. We demonstrate that, by using a single xenon flash lamp, we can image both a black latex cord placed in chicken breast tissue at a depth of up to 3.5 cm ex vivo and an entire mouse body in vivo. Our findings indicate that the xenon flash lamp, producing optical illumination that is safe for humans, can be potentially applied to human tissue imaging.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Terence T. W. Wong ; Yong Zhou ; Alejandro Garcia-Uribe ; Lei Li ; Konstantin Maslov, et al.
"Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo", J. Biomed. Opt. 22(4), 041003 (Oct 24, 2016). ; http://dx.doi.org/10.1117/1.JBO.22.4.041003


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