Special Section on Adaptive Optics and Wavefront Control for Biological Systems

Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography

[+] Author Affiliations
Hyeonseung Yu, YoungJu Jo, KyeoReh Lee, YongKeun Park

Korea Advanced Institute of Science and Technology, Department of Physics, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea

KAIST Institute of Health Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea

Peter Lee, Yong Jeong

KAIST Institute of Health Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea

Korea Advanced Institute of Science and Technology, Department of Bio and Brain Engineering, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea

Valery V. Tuchin

Saratov National Research State University, Research-Education Institute of Optics and Biophotonics, 83, Astrakhanskaya Street, Saratov 410012, Russia

Institute of Precision Mechanics and Control of Russian Academy of Sciences, Laboratory of Laser Diagnostics of Technical and Living Systems, 24, Rabochaya Street, Saratov 410028, Russia

National Research Tomsk State University, Laboratory of Biophotonics, 36, Lenin’s Avenue, Tomsk 634050, Russia

J. Biomed. Opt. 21(12), 121510 (Oct 28, 2016). doi:10.1117/1.JBO.21.12.121510
History: Received May 17, 2016; Accepted October 5, 2016
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Abstract.  We demonstrate that simultaneous application of optical clearing agents (OCAs) and complex wavefront shaping in optical coherence tomography (OCT) can provide significant enhancement of penetration depth and imaging quality. OCA reduces optical inhomogeneity of a highly scattering sample, and the wavefront shaping of illumination light controls multiple scattering, resulting in an enhancement of the penetration depth and signal-to-noise ratio. A tissue phantom study shows that concurrent applications of OCA and wavefront shaping successfully operate in OCT imaging. The penetration depth enhancement is further demonstrated for ex vivo mouse ears, revealing hidden structures inaccessible with conventional OCT imaging.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Hyeonseung Yu ; Peter Lee ; YoungJu Jo ; KyeoReh Lee ; Valery V. Tuchin, et al.
"Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography", J. Biomed. Opt. 21(12), 121510 (Oct 28, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.12.121510


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