Research Papers: Imaging

Imaging technique for real-time temperature monitoring during cryotherapy of lesions

[+] Author Affiliations
Elena Petrova, Vyacheslav Nadvoretskiy

Tomowave Laboratories, Inc., 6550 Mapleridge Street, Suite 124, Houston, Texas 77081-4629, United States

Anton Liopo

Tomowave Laboratories, Inc., 6550 Mapleridge Street, Suite 124, Houston, Texas 77081-4629, United States

Pinami, LLC, 10718 Silkwood Drive, Houston, Texas 77031, United States

Sergey Ermilov

Tomowave Laboratories, Inc., 6550 Mapleridge Street, Suite 124, Houston, Texas 77081-4629, United States

PhotoSound Technologies, Inc., 5658 Sylmar Street, Houston, Texas 77081, United States

J. Biomed. Opt. 21(11), 116007 (Nov 08, 2016). doi:10.1117/1.JBO.21.11.116007
History: Received August 9, 2016; Accepted October 10, 2016
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Abstract.  Noninvasive real-time temperature imaging during thermal therapies is able to significantly improve clinical outcomes. An optoacoustic (OA) temperature monitoring method is proposed for noninvasive real-time thermometry of vascularized tissue during cryotherapy. The universal temperature-dependent optoacoustic response (ThOR) of red blood cells (RBCs) is employed to convert reconstructed OA images to temperature maps. To obtain the temperature calibration curve for intensity-normalized OA images, we measured ThOR of 10 porcine blood samples in the range of temperatures from 40°C to 16°C and analyzed the data for single measurement variations. The nonlinearity (ΔTmax) and the temperature of zero OA response (T0) of the calibration curve were found equal to 11.4±0.1°C and 13.8±0.1°C, respectively. The morphology of RBCs was examined before and after the data collection confirming cellular integrity and intracellular compartmentalization of hemoglobin. For temperatures below 0°C, which are of particular interest for cryotherapy, the accuracy of a single temperature measurement was ±1°C, which is consistent with the clinical requirements. Validation of the proposed OA temperature imaging technique was performed for slow and fast cooling of blood samples embedded in tissue-mimicking phantoms.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Elena Petrova ; Anton Liopo ; Vyacheslav Nadvoretskiy and Sergey Ermilov
"Imaging technique for real-time temperature monitoring during cryotherapy of lesions", J. Biomed. Opt. 21(11), 116007 (Nov 08, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.11.116007


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