In general, both ultrasound and OCT-based SWEI using a limited number of shear sources with moving-detector tracking provides quantitative and repeatable measurement of elastic properties within highly scattering tissue. The previous literature18 did provide an OCE-based method combining ARF and PhS-OCT to assess aged-related changes in the crystalline lens in situ. Either maximum displacement or model-based temporal analysis identifies age-related changes. However, the displacement can only be tracked on the lens surface, which has significant speckle, and the measurement appears to be a point detection even though it reflects the average elastic properties of the whole lens. The elasticity of the lens, including the cortex and nucleus, is fundamentally heterogeneous. For this relatively transparent tissue producing very low amplitude OCT signals (i.e., low echogenicity and even truly speckle-free regions), however, it is difficult for OCT to measure tissue displacement because the signal-to-noise ratio (SNR) is too low to reliably extract useful phase information. For this reason, it is almost impossible for OCT to track displacements within the interior region of the crystalline lens in the eye. Therefore, a different technique is needed to map the heterogeneous elastic modulus within the interior of the lens. Here, we present a potential solution using moving-source OCE to assess the elastic properties within weakly scattering or truly speckle-free regions.