Research Papers: Imaging

Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography

[+] Author Affiliations
Vladimir Y. Zaitsev, Alexander L. Matveyev, Lev A. Matveev, Grigory V. Gelikonov

Institute of Applied Physics, Russian Academy of Sciences, 46 Uljanova Street, Nizhny Novgorod 603950, Russia

Medical Academy of Nizhny Novgorod, 1 Minina Square, 10/1 Minina Square, Nizhny Novgorod 603005, Russia

Aleksandr A. Sovetsky

Institute of Applied Physics, Russian Academy of Sciences, 46 Uljanova Street, Nizhny Novgorod 603950, Russia

Alex Vitkin

Medical Academy of Nizhny Novgorod, 1 Minina Square, 10/1 Minina Square, Nizhny Novgorod 603005, Russia

University Health Network and University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada

J. Biomed. Opt. 21(11), 116005 (Nov 08, 2016). doi:10.1117/1.JBO.21.11.116005
History: Received June 1, 2016; Accepted October 18, 2016
Text Size: A A A

Abstract.  In compressional optical coherence elastography, phase-variation gradients are used for estimating quasistatic strains created in tissue. Using reference and deformed optical coherence tomography (OCT) scans, one typically compares phases from pixels with the same coordinates in both scans. Usually, this limits the allowable strains to fairly small values <104 to 103, with the caveat that such weak phase gradients may become corrupted by stronger measurement noises. Here, we extend the OCT phase-resolved elastographic methodology by (1) showing that an order of magnitude greater strains can significantly increase the accuracy of derived phase-gradient differences, while also avoiding error-phone phase-unwrapping procedures and minimizing the influence of decorrelation noise caused by suprapixel displacements, (2) discussing the appearance of artifactual stiff inclusions in resultant OCT elastograms in the vicinity of bright scatterers due to the amplitude-phase interplay in phase-variation measurements, and (3) deriving/evaluating methods of phase-gradient estimation that can outperform conventionally used least-square gradient fitting. We present analytical arguments, numerical simulations, and experimental examples to demonstrate the advantages of the proposed optimized phase-variation methodology.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Vladimir Y. Zaitsev ; Alexander L. Matveyev ; Lev A. Matveev ; Grigory V. Gelikonov ; Aleksandr A. Sovetsky, et al.
"Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography", J. Biomed. Opt. 21(11), 116005 (Nov 08, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.11.116005


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Optical clearing at cellular level. J Biomed Opt 2014;19(7):71409.
Functional imaging for regenerative medicine. Stem Cell Res Ther 2016;7(1):57.
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.