To date, only a limited number of studies have reported the use of IR or near-IR (NIR) laser treatment with mesoporous silica; however, they require the use of gold cores and the associated plasmonic resonance in response to the laser photons. For example, Volodkin et al.47 demonstrated that gold cores inside MSNP pores could be heated with NIR light to transfer heat to liposome bilayer cargo to release encapsulated dye molecules, while Mura et al.48 reported that an increase in temperature of NIR-treated gold nanoparticle cores caused a phase transition in polymers capping mesoporous silica shells, allowing leakage of a preloaded drug. Chen et al.49 further illustrated that mesoporous silica shells encapsulating gold nanorod cores provided mechanical support against thermal deformation following laser irradiation, compared to uncoated nanorods. While these reports used NIR treatment with mesoporous silica components, it was the gold particles that were responsible for thermo-responsiveness through plasmon resonance and two-photon-activated therapy of photosensitizers. Such investigations are useful for strategies to eradicate or harm tissues, e.g., in cancer applications,50 but are not suitable for applications in highly specialized reproductive cells and tissues, which need to safely transmit genetic information to future generations.51 It is known that the toxicity of gold nanomaterials varies widely and in a dose-dependent manner.52 Additionally, gold nanostructures are known to irreversibly deform under even very low-energy stimulus, resulting in a spectral shift of peak surface plasmon resonance absorption, thereby reducing the efficiency of any photon or laser-induced methods, and have also been shown to be cytotoxic in mammalian cells following laser-induced modifications.49,53 In contrast, our present study investigated the use of MSNPs alone with IR laser treatment to increase the expression of MSNP cargo naturally via normal cellular machinery, illustrating that a heat-stimulus response can be achieved without the use of two-photon-activation using gold cores, which is highly desirable for investigations in the reproductive sciences.