Special Section on Photoacoustic Imaging and Sensing

Microsphere enabled subdiffraction-limited optical-resolution photoacoustic microscopy: a simulation study

[+] Author Affiliations
Paul Kumar Upputuri, Moganasundari Krisnan, Manojit Pramanik

Nanyang Technological University, School of Chemical and Biomedical Engineering, 62 Nanyang Drive, Singapore 637459, Singapore

J. Biomed. Opt. 22(4), 045001 (Nov 30, 2016). doi:10.1117/1.JBO.22.4.045001
History: Received August 15, 2016; Accepted November 7, 2016
Text Size: A A A

Abstract.  Optical resolution photoacoustic microscopy (ORPAM) is a high-resolution hybrid imaging modality having potential for microscale in vivo imaging. Optical diffraction limits the lateral resolution of ORPAM. A photonic nanojet (PNJ) was used to break this diffraction limit. A single round microsphere can generate a PNJ with subwavelength waist, but its short axial length limits its applications to surface imaging only. We investigate different sphere designs to achieve ultralong nanojets that will make the nanojet more viable in far-field applications, such as photoacoustic imaging. The PNJ properties, including effective length, waist size, working distance, and peak intensity, can be tuned and controlled by changing the sphere design and its refractive index. A truncated multilayer microsphere design could generate an ultraelongated PNJ with length larger than 172λ(138  μm) while retaining a large working distance 32λ(26  μm). Through simulation study, we observed 11-fold enhancement in lateral resolution with 5  μm round sphere (refractive index 2.2) when used in a conventional ORPAM setup with NA=0.1 and λ=800  nm.

Figures in this Article
© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Paul Kumar Upputuri ; Moganasundari Krisnan and Manojit Pramanik
"Microsphere enabled subdiffraction-limited optical-resolution photoacoustic microscopy: a simulation study", J. Biomed. Opt. 22(4), 045001 (Nov 30, 2016). ; http://dx.doi.org/10.1117/1.JBO.22.4.045001


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.