Research Papers: General

Early discrimination of nasopharyngeal carcinoma based on tissue deoxyribose nucleic acid surface-enhanced Raman spectroscopy analysis

[+] Author Affiliations
Sufang Qiu, Jianji Pan

Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Department of Radiation Oncology, No. 420, Fuma Road, Fuzhou 350014, Fujian, China

Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian 350122, China

Chao Li, Yuanji Xu

The Shengli Clinical College of Fujian Medical University, Fuzhou, Fujian 350001, China

Jinyong Lin, Jun Lu, Qingting Huang

Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Department of Radiation Oncology, No. 420, Fuma Road, Fuzhou 350014, Fujian, China

Changyan Zou, Chao Chen

Fujian Provincial Cancer Hospital, Fujian Medical University Cancer Hospital, Department of Radiation Biological Laboratory, Fuzhou, Fujian 350014, China

Nanyang Xiao

Fujian Normal University, The Key Laboratories of Innate Immune Biology of Fujian Province, Southern Biomedical Research Center, Fuzhou 350007, China

Duo Lin

Fujian Normal University, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fuzhou 350007, China

Fujian University of Traditional Chinese Medicine, College of Integrated Traditional Chinese and Western Medicine, Fuzhou 350108, China

Rong Chen, Shangyuan Feng

Fujian Normal University, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fuzhou 350007, China

J. Biomed. Opt. 21(12), 125003 (Dec 09, 2016). doi:10.1117/1.JBO.21.12.125003
History: Received August 25, 2016; Accepted November 21, 2016
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Abstract.  Surface-enhanced Raman spectroscopy (SERS) was employed to detect deoxyribose nucleic acid (DNA) variations associated with the development of nasopharyngeal carcinoma (NPC). Significant SERS spectral differences between the DNA extracted from early NPC, advanced NPC, and normal nasopharyngeal tissue specimens were observed at 678, 729, 788, 1337, 1421, 1506, and 1573  cm1, which reflects the genetic variations in NPC. Principal component analysis combined with discriminant function analysis for early NPC discrimination yielded a diagnostic accuracy of 86.8%, 92.3%, and 87.9% for early NPC, advanced NPC, and normal nasopharyngeal tissue DNA, respectively. In this exploratory study, we demonstrated the potential of SERS for early detection of NPC based on the DNA molecular study of biopsy tissues.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Sufang Qiu ; Chao Li ; Jinyong Lin ; Yuanji Xu ; Jun Lu, et al.
"Early discrimination of nasopharyngeal carcinoma based on tissue deoxyribose nucleic acid surface-enhanced Raman spectroscopy analysis", J. Biomed. Opt. 21(12), 125003 (Dec 09, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.12.125003


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