Research Papers: Therapeutic

Sensitized TiO2 nanocomposites through HMME linkage for photodynamic effects

[+] Author Affiliations
Yu Lu He, Sijia Wang, Luwei Zhang, Jing Xin, Jing Wang, Cuiping Yao, Zhenxi Zhang

Xi’an Jiaotong University, Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, No. 28, Xianning West Road, Xi’an, Shaanxi 710049, China

Chih-Chung Yang

National Taiwan University, Institute of Photonics and Optoelectronics, No. 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan

J. Biomed. Opt. 21(12), 128001 (Dec 15, 2016). doi:10.1117/1.JBO.21.12.128001
History: Received August 10, 2016; Accepted November 21, 2016
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Abstract.  Although TiO2 can be used to effectively generate reactive oxygen species (ROS) for photodynamic application, its absorption in the ultraviolet range makes the excitation harmful to tissue. Based on the concept of a sensitized solar cell, TiO2 nanoparticles (NPs) are sensitized by linking with the photosensitizer, HMME, to form HMME-TiO2 nanocomposites (NCs) for demonstrating the photodynamic effects under the illumination of white light. The HMME-TiO2 NCs of different composition ratios are prepared for maximizing the generation of ROS and optimizing the inactivation effect of KB cells. The material characteristics and the ROS generation capability of the HMME-TiO2 NCs with the optimized combination ratio show their merits in a photodynamic process under white light irradiation. The application of such NCs to KB cell experiments results in a higher inactivation efficiency when compared to pure HMME of the same concentration.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Yu Lu He ; Sijia Wang ; Luwei Zhang ; Jing Xin ; Jing Wang, et al.
"Sensitized TiO2 nanocomposites through HMME linkage for photodynamic effects", J. Biomed. Opt. 21(12), 128001 (Dec 15, 2016). ; http://dx.doi.org/10.1117/1.JBO.21.12.128001


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