Sensitized TiO2 nanocomposites through HMME linkage for photodynamic effects

Yu Lu He; Sijia Wang; Luwei Zhang; Jing Xin; Jing Wang; Cuiping Yao; Zhenxi Zhang; Chih-Chung Yang

doi:10.1117/1.JBO.21.12.128001

15 December 2016 Sensitized TiO₂ nanocomposites through HMME linkage for photodynamic effects

Yu Lu He, Sijia Wang, Luwei Zhang, Jing Xin, Jing Wang, Cuiping Yao, Zhenxi Zhang, Chih-Chung Yang

Author Affiliations +

Journal of Biomedical Optics, Vol. 21, Issue 12, 128001 (December 2016). https://doi.org/10.1117/1.JBO.21.12.128001

Abstract

Although TiO₂ can be used to effectively generate reactive oxygen species (ROS) for photodynamic application, its absorption in the ultraviolet range makes the excitation harmful to tissue. Based on the concept of a sensitized solar cell, TiO₂ nanoparticles (NPs) are sensitized by linking with the photosensitizer, HMME, to form HMME-TiO₂ nanocomposites (NCs) for demonstrating the photodynamic effects under the illumination of white light. The HMME-TiO₂ NCs of different composition ratios are prepared for maximizing the generation of ROS and optimizing the inactivation effect of KB cells. The material characteristics and the ROS generation capability of the HMME-TiO₂ NCs with the optimized combination ratio show their merits in a photodynamic process under white light irradiation. The application of such NCs to KB cell experiments results in a higher inactivation efficiency when compared to pure HMME of the same concentration.

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Yu Lu He, Sijia Wang, Luwei Zhang, Jing Xin, Jing Wang, Cuiping Yao, Zhenxi Zhang, and Chih-Chung Yang "Sensitized TiO₂ nanocomposites through HMME linkage for photodynamic effects," Journal of Biomedical Optics 21(12), 128001 (15 December 2016). https://doi.org/10.1117/1.JBO.21.12.128001

Published: 15 December 2016

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KEYWORDS

Absorption

Photodynamic therapy

Lamps

Luminescence

Nanocomposites

Xenon

Visible radiation

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