Special Section on Photoacoustic Imaging and Sensing

Toward the detection of intraplaque hemorrhage in carotid artery lesions using photoacoustic imaging

[+] Author Affiliations
Mustafa Umit Arabul, Maarten Heres, Marcel C. M. Rutten, Frans N. van de Vosse, Richard G. P. Lopata

Eindhoven University of Technology, Department of Biomedical Engineering, Cardiovascular Biomechanics Group, De Zaale, Eindhoven 5612 AJ, The Netherlands

Marc R. van Sambeek

Catharina Hospital Eindhoven, Department of Vascular Surgery, Michelangelolaan 2, Eindhoven 5623 EJ, The Netherlands

J. Biomed. Opt. 22(4), 041010 (Dec 23, 2016). doi:10.1117/1.JBO.22.4.041010
History: Received August 24, 2016; Accepted December 1, 2016
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Abstract.  Photoacoustic imaging (PAI) may have the ability to reveal the composition and the anatomical structure of carotid plaques, which determines its mechanical properties and vulnerability. We used PAI and plane wave ultrasound (PUS) imaging to obtain three-dimensional (3-D) images of endarterectomy samples ex vivo and compared the results with histology to investigate the potential of PAI-based identification of intraplaque hemorrhage. Seven carotid plaque samples were obtained from patients undergoing carotid endarterectomy and imaged with a fully integrated hand-held photoacoustic (PA) probe, consisting of a pulsed diode laser (tpulse=130  ns, Epulse=1  mJ, λ=808  nm) and a linear array transducer (fc=7.5  MHz). The samples were rotated 360 deg with 10 deg steps, and data were spatially compounded to obtain complete 3-D images of the plaques. Areas of high absorption in the 3-D datasets were identified and compared to histological data of the plaques. Data in six out of seven endarterectomy samples revealed the presence of intraplaque hemorrhages that were not visible in the PUS images. Due to the noninvasive nature of PAI, this ex vivo study may elucidate preclinical studies toward the in vivo, noninvasive, vulnerability assessment of the atherosclerotic carotid plaque.

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© 2016 Society of Photo-Optical Instrumentation Engineers

Citation

Mustafa Umit Arabul ; Maarten Heres ; Marcel C. M. Rutten ; Marc R. van Sambeek ; Frans N. van de Vosse, et al.
"Toward the detection of intraplaque hemorrhage in carotid artery lesions using photoacoustic imaging", J. Biomed. Opt. 22(4), 041010 (Dec 23, 2016). ; http://dx.doi.org/10.1117/1.JBO.22.4.041010


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