Research Papers: Imaging

Design of a portable imager for near-infrared visualization of cutaneous wounds

[+] Author Affiliations
Zhaoqiang Peng, Deyin Zhao, Weidong Zhou

University of Texas at Arlington, Department of Electrical Engineering, P.O. Box 19016, Arlington, Texas 76019, United States

Jun Zhou, Ashley Dacy, Vasant Kearney, Liping Tang

University of Texas at Arlington, Department of Bioengineering, P.O. Box 19138, Arlington, Texas 76019, United States

Wenjing Hu

Progenitec Inc., 917 Parktree Drive, Arlington, Texas 76015, United States

J. Biomed. Opt. 22(1), 016010 (Jan 13, 2017). doi:10.1117/1.JBO.22.1.016010
History: Received July 6, 2016; Accepted December 27, 2016
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Abstract.  A portable imager developed for real-time imaging of cutaneous wounds in research settings is described. The imager consists of a high-resolution near-infrared CCD camera capable of detecting both bioluminescence and fluorescence illuminated by an LED ring with a rotatable filter wheel. All external components are integrated into a compact camera attachment. The device is demonstrated to have competitive performance with a commercial animal imaging enclosure box setup in beam uniformity and sensitivity. Specifically, the device was used to visualize the bioluminescence associated with increased reactive oxygen species activity during the wound healing process in a cutaneous wound inflammation model. In addition, this device was employed to observe the fluorescence associated with the activity of matrix metalloproteinases in a mouse lipopolysaccharide-induced infection model. Our results support the use of the portable imager design as a noninvasive and real-time imaging tool to assess the extent of wound inflammation and infection.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Zhaoqiang Peng ; Jun Zhou ; Ashley Dacy ; Deyin Zhao ; Vasant Kearney, et al.
"Design of a portable imager for near-infrared visualization of cutaneous wounds", J. Biomed. Opt. 22(1), 016010 (Jan 13, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.1.016010


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