Research Papers: General

Modeling of diffuse reflectance of light in heterogeneous biological tissue to analysis of the effects of multiple scattering on reflectance pulse oximetry

[+] Author Affiliations
Mohsen Mehrabi, Saeed Setayeshi

Amirkabir University of Technology, Department of Medical Radiation Engineering, 424 Hafez Avenue, Tehran 15875-4413, Iran

Seyed Hossein Ardehali

Shahid Beheshti University of Medical Sciences, Department of Anesthesiology and Critical Care, Shohadaye Tajrish Hospital, Tajrish Square, Tehran 19899-34148, Iran

Hossein Arabalibeik

Tehran University of Medical Sciences, Research Center for Biomedical Technology and Robotics, Imam Khomeini Hospital complex, Keshavarz Boulevard, Tehran 14197-33141, Iran

J. Biomed. Opt. 22(1), 015004 (Jan 19, 2017). doi:10.1117/1.JBO.22.1.015004
History: Received July 26, 2016; Accepted December 19, 2016
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Abstract.  Fingertip-type pulse oximeters are popular, but their inconvenience for long-term monitoring in daily life means that other types of wearable pulse oximeters, such as reflectance pulse oximeters, need to be developed. For the purpose of developing reflection pulse oximetry, we have analyzed the light propagation in tissue to calculate and estimate the measured intensities of reflected light using the analytical and numerical solutions of the diffusion approximation equation. The reflectance of light from the biological tissue is investigated from theoretical and experimental perspectives, for light in the visible and near-infrared wavelengths. To establish the model, the calculated curves were compared with the analytical solution (AS) of the diffusion approximation equation in biological tissue. The results validated that the diffusion approximation equation could resolve the heterogeneous advanced tissue and the finite element method (FEM) could offer the simulation with higher efficiency and accuracy. Our aim has been to demonstrate the power of the FEM and AS in modeling of the steady-state diffusion approximation in a heterogeneous medium. Also, experimental data and the Monte Carlo model as a gold standard were used to verify the effectiveness of these methods.

© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Mohsen Mehrabi ; Saeed Setayeshi ; Seyed Hossein Ardehali and Hossein Arabalibeik
"Modeling of diffuse reflectance of light in heterogeneous biological tissue to analysis of the effects of multiple scattering on reflectance pulse oximetry", J. Biomed. Opt. 22(1), 015004 (Jan 19, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.1.015004


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