Research Papers: Sensing

Modeling-based design and assessment of an acousto-optic guided high-intensity focused ultrasound system

[+] Author Affiliations
Matthew T. Adams

Boston University, Department of Mechanical Engineering, 110 Cummington Mall, Boston, Massachusetts 02215, United States

University of Oxford, Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, Oxford OX3 7DQ, United Kingdom

Robin O. Cleveland

University of Oxford, Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, Oxford OX3 7DQ, United Kingdom

Ronald A. Roy

University of Oxford, Department of Engineering Science, 9 Parks Road, Oxford OX1 3PJ, United Kingdom

J. Biomed. Opt. 22(1), 017001 (Jan 23, 2017). doi:10.1117/1.JBO.22.1.017001
History: Received September 27, 2016; Accepted December 27, 2016
Text Size: A A A

Abstract.  Real-time acousto-optic (AO) sensing has been shown to noninvasively detect changes in ex vivo tissue optical properties during high-intensity focused ultrasound (HIFU) exposures. The technique is particularly appropriate for monitoring noncavitating lesions that offer minimal acoustic contrast. A numerical model is presented for an AO-guided HIFU system with an illumination wavelength of 1064 nm and an acoustic frequency of 1.1 MHz. To confirm the model’s accuracy, it is compared to previously published experimental data gathered during AO-guided HIFU in chicken breast. The model is used to determine an optimal design for an AO-guided HIFU system, to assess its robustness, and to predict its efficacy for the ablation of large volumes. It was found that a through transmission geometry results in the best performance, and an optical wavelength around 800 nm was optimal as it provided sufficient contrast with low absorption. Finally, it was shown that the strategy employed while treating large volumes with AO guidance has a major impact on the resulting necrotic volume and symmetry.

Figures in this Article
© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Matthew T. Adams ; Robin O. Cleveland and Ronald A. Roy
"Modeling-based design and assessment of an acousto-optic guided high-intensity focused ultrasound system", J. Biomed. Opt. 22(1), 017001 (Jan 23, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.1.017001


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.