Special Section on Photoacoustic Imaging and Sensing

Generation of anatomically realistic numerical phantoms for photoacoustic and ultrasonic breast imaging

[+] Author Affiliations
Yang Lou, Thomas P. Matthews

Washington University in St. Louis, Department of Biomedical Engineering, 1 Brookings Drive, St. Louis, Missouri 63130, United States

Weimin Zhou

Washington University in St. Louis, Department of Electrical and Systems Engineering, 1 Brookings Drive, St. Louis, Missouri 63130, United States

Catherine M. Appleton

Washington University in St. Louis, Mallinckrodt Institute of Radiology, 1 Brookings Drive, St. Louis, Missouri 63130, United States

Mark A. Anastasio

Washington University in St. Louis, Department of Biomedical Engineering, 1 Brookings Drive, St. Louis, Missouri 63130, United States

Washington University in St. Louis, Department of Electrical and Systems Engineering, 1 Brookings Drive, St. Louis, Missouri 63130, United States

Washington University in St. Louis, Mallinckrodt Institute of Radiology, 1 Brookings Drive, St. Louis, Missouri 63130, United States

J. Biomed. Opt. 22(4), 041015 (Jan 31, 2017). doi:10.1117/1.JBO.22.4.041015
History: Received September 6, 2016; Accepted December 28, 2016
Text Size: A A A

Abstract.  Photoacoustic computed tomography (PACT) and ultrasound computed tomography (USCT) are emerging modalities for breast imaging. As in all emerging imaging technologies, computer-simulation studies play a critically important role in developing and optimizing the designs of hardware and image reconstruction methods for PACT and USCT. Using computer-simulations, the parameters of an imaging system can be systematically and comprehensively explored in a way that is generally not possible through experimentation. When conducting such studies, numerical phantoms are employed to represent the physical properties of the patient or object to-be-imaged that influence the measured image data. It is highly desirable to utilize numerical phantoms that are realistic, especially when task-based measures of image quality are to be utilized to guide system design. However, most reported computer-simulation studies of PACT and USCT breast imaging employ simple numerical phantoms that oversimplify the complex anatomical structures in the human female breast. We develop and implement a methodology for generating anatomically realistic numerical breast phantoms from clinical contrast-enhanced magnetic resonance imaging data. The phantoms will depict vascular structures and the volumetric distribution of different tissue types in the breast. By assigning optical and acoustic parameters to different tissue structures, both optical and acoustic breast phantoms will be established for use in PACT and USCT studies.

Figures in this Article
© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Yang Lou ; Weimin Zhou ; Thomas P. Matthews ; Catherine M. Appleton and Mark A. Anastasio
"Generation of anatomically realistic numerical phantoms for photoacoustic and ultrasonic breast imaging", J. Biomed. Opt. 22(4), 041015 (Jan 31, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.4.041015


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.