Special Series on Translational Biophotonics

Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study

[+] Author Affiliations
Paulien L. Stegehuis

Leiden University Medical Center, Department of Surgery, Leiden, The Netherlands

Leiden University Medical Center, Department of Radiology, Leiden, The Netherlands

Leonora S. F. Boogerd, P. van Gerven, Bert A. Bonsing, J. Sven Mieog, Cornelis J. H. van de Velde, Alexander L. Vahrmeijer

Leiden University Medical Center, Department of Surgery, Leiden, The Netherlands

Akin Inderson, Roeland A. Veenendaal

Leiden University Medical Center, Department of Gastroenterology and Hepatology, Leiden, The Netherlands

Arjen Amelink

Netherlands Organisation for Applied Scientific Research TNO, Department of Optics, Delft, The Netherlands

Maud Veselic, Hans Morreau

Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands

Boudewijn P. F. Lelieveldt, Jouke Dijkstra

Leiden University Medical Center, Department of Radiology, Leiden, The Netherlands

Dominic J. Robinson

Center for Optical Diagnostics and Therapy, Department of Otolaryngology and Head and Neck Surgery, Erasmus MC, Rotterdam, The Netherlands

J. Biomed. Opt. 22(2), 024001 (Feb 06, 2017). doi:10.1117/1.JBO.22.2.024001
History: Received November 16, 2016; Accepted January 12, 2017
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Abstract.  Endoscopic ultrasound-guided fine needle aspirations (EUS-FNA) of pancreatic masses suffer from sample errors and low-negative predictive values. Fiber-optic spectroscopy in the visible to near-infrared wavelength spectrum can noninvasively extract physiological parameters from tissue and has the potential to guide the sampling process and reduce sample errors. We assessed the feasibility of single fiber (SF) reflectance spectroscopy measurements during EUS-FNA of pancreatic masses and its ability to distinguish benign from malignant pancreatic tissue. A single optical fiber was placed inside a 19-gauge biopsy needle during EUS-FNA and at least three reflectance measurements were taken prior to FNA. Spectroscopy measurements did not cause any related adverse events and prolonged procedure time with 5  min. An accurate correlation between spectroscopy measurements and cytology could be made in nine patients (three benign and six malignant). The oxygen saturation and bilirubin concentration were significantly higher in benign tissue compared with malignant tissue (55% versus 21%, p=0.038; 166  μmol/L versus 17  μmol/L, p=0.039, respectively). To conclude, incorporation of SF spectroscopy during EUS-FNA was feasible, safe, and relatively quick to perform. The optical properties of benign and malignant pancreatic tissue are different, implying that SF spectroscopy can potentially guide the FNA sampling.

Figures in this Article
© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Paulien L. Stegehuis ; Leonora S. F. Boogerd ; Akin Inderson ; Roeland A. Veenendaal ; P. van Gerven, et al.
"Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study", J. Biomed. Opt. 22(2), 024001 (Feb 06, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.2.024001


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