Special Section on Photoacoustic Imaging and Sensing

Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy

[+] Author Affiliations
Kenneth J. Furdella, Jonathan P. Vande Geest

University of Pittsburgh, Department of Bioengineering, Pittsburgh, Pennsylvania, United States

Russell S. Witte

University of Arizona, Department of Medical Imaging, Tucson, Arizona, United States

J. Biomed. Opt. 22(4), 041016 (Feb 13, 2017). doi:10.1117/1.JBO.22.4.041016
History: Received September 15, 2016; Accepted January 20, 2017
Text Size: A A A

Abstract.  Although the drug-eluting stent (DES) has dramatically reduced the rate of coronary restenosis, it still occurs in up to 20% of patients with a DES. Monitoring drug delivery could be one way to decrease restenosis rates. We demonstrate real-time photoacoustic imaging and spectroscopy (PAIS) using a wavelength-tunable visible laser and clinical ultrasound scanner to track cardiac drug delivery. The photoacoustic signal was initially calibrated using porcine myocardial samples soaked with a known concentration of a drug surrogate (DiI). Next, an in situ coronary artery was perfused with DiI for 20 min and imaged to monitor dye transport in the tissue. Finally, a partially DiI-coated stent was inserted into the porcine brachiocephalic trunk for imaging. The photoacoustic signal was proportional to the DiI concentration between 2.4 and 120  μg/ml, and the dye was detected over 1.5 mm from the targeted coronary vessel. Photoacoustic imaging was also able to differentiate the DiI-coated portion of the stent from the uncoated region. These results suggest that PAIS can track drug delivery to cardiac tissue and detect drugs loaded onto a stent with sub-mm precision. Future work using PAIS may help improve DES design and reduce the probability of restenosis.

Figures in this Article
© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Kenneth J. Furdella ; Russell S. Witte and Jonathan P. Vande Geest
"Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy", J. Biomed. Opt. 22(4), 041016 (Feb 13, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.4.041016


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


 

  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.