JBO Letters

Applanation optical coherence elastography: noncontact measurement of intraocular pressure, corneal biomechanical properties, and corneal geometry with a single instrument

[+] Author Affiliations
Manmohan Singh, Zhaolong Han, Achuth Nair, Alexander Schill

University of Houston, Department of Biomedical Engineering, Houston, Texas, United States

Michael D. Twa

University of Alabama at Birmingham, School of Optometry, Birmingham, Alabama, United States

Kirill V. Larin

University of Houston, Department of Biomedical Engineering, Houston, Texas, United States

Tomsk State University, Interdisciplinary Laboratory of Biophotonics, Tomsk, Russia

Baylor College of Medicine, Molecular Physiology and Biophysics, Houston, Texas, United States

J. Biomed. Opt. 22(2), 020502 (Feb 20, 2017). doi:10.1117/1.JBO.22.2.020502
History: Received November 8, 2016; Accepted January 30, 2017
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Abstract.  Current clinical tools provide critical information about ocular health such as intraocular pressure (IOP). However, they lack the ability to quantify tissue material properties, which are potent markers for ocular tissue health and integrity. We describe a single instrument to measure the eye-globe IOP, quantify corneal biomechanical properties, and measure corneal geometry with a technique termed applanation optical coherence elastography (Appl-OCE). An ultrafast OCT system enabled visualization of corneal dynamics during noncontact applanation tonometry and direct measurement of micro air-pulse induced elastic wave propagation. Our preliminary results show that the proposed Appl-OCE system can be used to quantify IOP, corneal biomechanical properties, and corneal geometry, which builds a solid foundation for a unique device that can provide a more complete picture of ocular health.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Manmohan Singh ; Zhaolong Han ; Achuth Nair ; Alexander Schill ; Michael D. Twa, et al.
"Applanation optical coherence elastography: noncontact measurement of intraocular pressure, corneal biomechanical properties, and corneal geometry with a single instrument", J. Biomed. Opt. 22(2), 020502 (Feb 20, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.2.020502


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