Special Section on Photoacoustic Imaging and Sensing

Dry coupling for whole-body small-animal photoacoustic computed tomography

[+] Author Affiliations
Chenghung Yeh, Lei Li

Washington University, Department of Electrical and Systems Engineering, St. Louis, Missouri, United States

Liren Zhu, Chiye Li, Wanyi Chen, Alejandro Garcia-Uribe, Konstantin I. Maslov

Washington University, Department of Biomedical Engineering, St. Louis, Missouri, United States

Jun Xia

University at Buffalo, Department of Biomedical Engineering, Buffalo, New York, United States

Lihong V. Wang

Washington University, Department of Electrical and Systems Engineering, St. Louis, Missouri, United States

Washington University, Department of Biomedical Engineering, St. Louis, Missouri, United States

J. Biomed. Opt. 22(4), 041017 (Feb 23, 2017). doi:10.1117/1.JBO.22.4.041017
History: Received August 10, 2016; Accepted February 8, 2017
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Abstract.  We have enhanced photoacoustic computed tomography with dry acoustic coupling that eliminates water immersion anxiety and wrinkling of the animal and facilitates incorporating complementary modalities and procedures. The dry acoustic coupler is made of a tubular elastic membrane enclosed by a closed transparent water tank. The tubular membrane ensures water-free contact with the animal, and the closed water tank allows pressurization for animal stabilization. The dry coupler was tested using a whole-body small-animal ring-shaped photoacoustic computed tomography system. Dry coupling was found to provide image quality comparable to that of conventional water coupling.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Chenghung Yeh ; Lei Li ; Liren Zhu ; Jun Xia ; Chiye Li, et al.
"Dry coupling for whole-body small-animal photoacoustic computed tomography", J. Biomed. Opt. 22(4), 041017 (Feb 23, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.4.041017


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