Research Papers: Imaging

In vivo photoacoustic imaging of blood vessels using a homodyne interferometer with zero-crossing triggering

[+] Author Affiliations
Jiao Lu, Yingzhe Gao, Zhenhe Ma, Hongxian Zhou, Yi Wang

Northeastern University at Qinhuangdao, School of Control Engineering, Qinhuangdao, China

Ruikang K. Wang

University of Washington, Department of Bioengineering, Seattle, Washington, United States

J. Biomed. Opt. 22(3), 036002 (Mar 02, 2017). doi:10.1117/1.JBO.22.3.036002
History: Received November 30, 2016; Accepted February 10, 2017
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Abstract.  We demonstrate a quasinoncontact photoacoustic imaging method using a homodyne interferometer with a long coherence length laser. The generated photoacoustic signal is detected by a system that is locked at its maximum sensitivity through the use of balanced detection and zero-crossing triggering. The balanced detector is substantially equalized, so its output is zero when the system reaches the maximum sensitivity. The synchronization approach is used to trigger the excitation and detection of the photoacoustic signal. The system is immune to ambient vibrations. A thin water layer on the sample surface is used to reduce the effect of the rough tissue surface. The performance of the system is demonstrated by in vivo imaging of the microvasculature in mouse ears.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Jiao Lu ; Yingzhe Gao ; Zhenhe Ma ; Hongxian Zhou ; Ruikang K. Wang, et al.
"In vivo photoacoustic imaging of blood vessels using a homodyne interferometer with zero-crossing triggering", J. Biomed. Opt. 22(3), 036002 (Mar 02, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.3.036002


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