Research Papers: General

Pilot clinical study to assess caries lesion activity using quantitative light-induced fluorescence during dehydration

[+] Author Affiliations
Masatoshi Ando, Domenick T. Zero

Indiana University School of Dentistry, Department of Cariology, Operative Dentistry and Dental Public Health, Indianapolis, Indiana, United States

Andrea G. Ferreira-Zandoná

University of North Carolina at Chapel Hill, School of Dentistry Department of Operative Dentistry, Chapel Hill, North Carolina, United States

George J. Eckert

Indiana University School of Medicine, Department of Biostatistics, Indianapolis, Indiana, United States

George K. Stookey

Therametric Technologies, Inc., Noblesville, Indiana, United States

J. Biomed. Opt. 22(3), 035005 (Mar 10, 2017). doi:10.1117/1.JBO.22.3.035005
History: Received December 15, 2016; Accepted February 21, 2017
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Abstract.  This study aimed to evaluate the ability of quantitative light-induced fluorescence (QLF) to assess caries lesion activity using visual examination (VE) as the gold standard. Twenty-four visible white spot lesions on buccal surfaces were examined from 23 children, ages 9 to 14 years. At baseline, the surface was hydrated with water, and thereafter, it was dehydrated with continuous compressed air during image acquisition. QLF images were acquired at 0 (baseline), 5, and 15 s. QLF variables [QLFV: fluorescence loss (ΔF), lesion size (S), ΔQ: ΔF×S] was recorded. Changes-in-QLFV per second (ΔQLFV) were determined: ΔQLFV=(QLFVNQLFVBaseline)/N, where N indicates dehydration time. One experienced dentist conducted VE independently using a dental unit’s light, compressed air, and explorer. QLFV and ΔQLFV of the active group (n=11) were compared with those of the inactive group (n=13) using two-sample t-tests. As the surface was dehydrated, S and ΔQ values of the active group increased, whereas QLFV of the inactive group showed only a small change. ΔQLFV of the active group were larger than those of the inactive group; however, the difference did not reach statistical significance (p>0.11). Within the limitations of this study, QLF data indicated increments for lesions designated as active and minimal change for lesions defined as inactive.

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© 2017 Society of Photo-Optical Instrumentation Engineers

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Citation

Masatoshi Ando ; Andrea G. Ferreira-Zandoná ; George J. Eckert ; Domenick T. Zero and George K. Stookey
"Pilot clinical study to assess caries lesion activity using quantitative light-induced fluorescence during dehydration", J. Biomed. Opt. 22(3), 035005 (Mar 10, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.3.035005


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