One of our primary goals in SFDI instrument development is to increase the data acquisition rate, which mainly relies on three parameters: image resolution, number of phase shifted patterns, and number of wavelengths. From the perspective of the single pixel camera, higher image resolution requires increasing the number of sampling patterns on the DMD to achieve a certain accuracy of reconstruction. We have chosen our optimum image resolution based on the transport scattering length in tissue (), which is typically in the NIR. Thus, for in a FOV, the pixel size is about 0.55 mm, which is adequate and comparable to . A sampling rate of about 10%, i.e., 400 samples, is adequate for a tissue phantom illuminated with sinusoidal patterns at a spatial frequency of . This sampling rate results in a maximum acquisition rate of 12.5 frames per second (FPS) on our DMD. However, other DMD chips, such as DLP7000 (Texas Instruments, Dallas, Texas) provide refresh rates of 32,550 Hz and acquisition rates of up to 80 FPS. Because cs-SFDI uses high-bandwidth single pixel detectors, spectral content can be increased using frequency encoding without reductions in image acquisition speed. In the current cs-SFDI configuration, the linear translational stage used for shifting the sinusoidal phase pattern is a limiting factor in achieving higher frame rates and switching between multiple spatial frequencies. As a result, it takes 5 s in total to switch among three phase-shifted frames and capture images. Recently, signal processing techniques in the SFD have been developed to reduce the number of phases required to achieve the demodulated reflectance and achieve “single snapshot” performance.20,21 These methods, however, require a high number of cycles in the modulation pattern to avoid ringing artifacts.20 This imposes faster sampling rates to preserve higher frequency content in the image, thus increasing acquisition time. Therefore, further studies are required to evaluate the fidelity and performance of the cs-SFDI system when using single snapshot demodulation techniques.