Research Papers: Sensing

Assessment of intraocular pressure sensing using an implanted reflective flexible membrane

[+] Author Affiliations
Andrey Nazarov, Ibrahim Abdulhalim

Ben-Gurion University of the Negev, Ilse Katz Institute for Nanoscale Science and Technology, Department of Electro-Optic Engineering, Beer-Sheva, Israel

Boris Knyazer, Tova Lifshitz

Ben-Gurion University of the Negev, Soroka University Medical Center, Department of Ophthalmology, Beer-Sheva, Israel

Mark Schvartzman

Ben-Gurion University of the Negev, Department of Material Engineering, Beer-Sheva, Israel

J. Biomed. Opt. 22(4), 047001 (Apr 05, 2017). doi:10.1117/1.JBO.22.4.047001
History: Received July 26, 2016; Accepted March 16, 2017
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Abstract.  Glaucoma is a neurodegenerative condition that is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is the main cause for the development of the disease. The symptoms of this form, such as deterioration of vision and scotomas (loss of visual fields), appear in the latter stages of the disease. Therefore, an IOP monitoring device is needed for better, simpler, and faster diagnosis, and to enable a fast treatment response. We present a theoretical assessment as well as preliminary experimental results of a simple approach for easy, optical, IOP self-monitoring. It is based on a polydimethylsiloxane membrane coated with a reflective layer and a Hartmann–Shack wavefront sensor. Nearly linear correlation is found between membrane deformation and Zernike coefficients representing defocus primary spherical aberration, with high sensitivity and negligible dependence on the measurement distance. The proposed device is expected to provide an accurate IOP measurement resolution of less than ±0.2  mmHg with a pressure dependence on working distances <0.7  mmHg/cm for a thick membrane; the corresponding values for a thin membrane are ±0.45  mmHg and <0.6  mmHg/cm, respectively, at typical IOP values—up to 40 mm Hg.

© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Andrey Nazarov ; Boris Knyazer ; Tova Lifshitz ; Mark Schvartzman and Ibrahim Abdulhalim
"Assessment of intraocular pressure sensing using an implanted reflective flexible membrane", J. Biomed. Opt. 22(4), 047001 (Apr 05, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.4.047001


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