Research Papers: Imaging

Excitation-resolved multispectral method for imaging pharmacokinetic parameters in dynamic fluorescent molecular tomography

[+] Author Affiliations
Maomao Chen, Yuan Zhou, Han Su, Dong Zhang

Tsinghua University, School of Medicine, Department of Biomedical Engineering, Beijing, China

Jianwen Luo

Tsinghua University, School of Medicine, Department of Biomedical Engineering, Beijing, China

Tsinghua University, Center for Biomedical Imaging Research, Beijing, China

J. Biomed. Opt. 22(4), 046003 (Apr 06, 2017). doi:10.1117/1.JBO.22.4.046003
History: Received February 3, 2017; Accepted March 15, 2017
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Abstract.  Imaging of the pharmacokinetic parameters in dynamic fluorescence molecular tomography (DFMT) can provide three-dimensional metabolic information for biological studies and drug development. However, owing to the ill-posed nature of the FMT inverse problem, the relatively low quality of the parametric images makes it difficult to investigate the different metabolic processes of the fluorescent targets with small distances. An excitation-resolved multispectral DFMT method is proposed; it is based on the fact that the fluorescent targets with different concentrations show different variations in the excitation spectral domain and can be considered independent signal sources. With an independent component analysis method, the spatial locations of different fluorescent targets can be decomposed, and the fluorescent yields of the targets at different time points can be recovered. Therefore, the metabolic process of each component can be independently investigated. Simulations and phantom experiments are carried out to evaluate the performance of the proposed method. The results demonstrated that the proposed excitation-resolved multispectral method can effectively improve the reconstruction accuracy of the parametric images in DFMT.

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Citation

Maomao Chen ; Yuan Zhou ; Han Su ; Dong Zhang and Jianwen Luo
"Excitation-resolved multispectral method for imaging pharmacokinetic parameters in dynamic fluorescent molecular tomography", J. Biomed. Opt. 22(4), 046003 (Apr 06, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.4.046003


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