Research Papers: General

Portable LED-induced autofluorescence spectroscopy for oral cancer diagnosis

[+] Author Affiliations
Yung-Jhe Yan

National Chiao-Tung University, Institute of Electrical Control Engineering, Hsinchu City, Taiwan

Ting-Wei Huang, Chin-Siang Yang

National Chiao-Tung University, Department of Electrical and Computer Engineering, Hsinchu City, Taiwan

Nai-Lun Cheng

National Chiao-Tung University, Institute of Biomedical Engineering, Hsinchu City, Taiwan

Yao-Fang Hsieh

National Central University, Department of Optics and Photonics, Jhongli City, Taoyuan County, Taiwan

Ming-Hsui Tsai, Jeng-Ren Duann, Yung-Jiun Lin

China Medical University, School of Medicine, Taichung City, Taiwan

Jin-Chern Chiou

National Chiao-Tung University, Institute of Electrical Control Engineering, Hsinchu City, Taiwan

National Chiao-Tung University, Department of Electrical and Computer Engineering, Hsinchu City, Taiwan

China Medical University, School of Medicine, Taichung City, Taiwan

Mang Ou-Yang

National Chiao-Tung University, Institute of Electrical Control Engineering, Hsinchu City, Taiwan

National Chiao-Tung University, Department of Electrical and Computer Engineering, Hsinchu City, Taiwan

J. Biomed. Opt. 22(4), 045007 (Apr 19, 2017). doi:10.1117/1.JBO.22.4.045007
History: Received August 30, 2016; Accepted March 7, 2017
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Abstract.  Oral cancer is a serious and growing problem in many developing and developed countries. To improve the cancer screening procedure, we developed a portable light-emitting-diode (LED)-induced autofluorescence (LIAF) imager that contains two wavelength LED excitation light sources and multiple filters to capture ex vivo oral tissue autofluorescence images. Compared with conventional means of oral cancer diagnosis, the LIAF imager is a handier, faster, and more highly reliable solution. The compact design with a tiny probe allows clinicians to easily observe autofluorescence images of hidden areas located in concave deep oral cavities. The ex vivo trials conducted in Taiwan present the design and prototype of the portable LIAF imager used for analyzing 31 patients with 221 measurement points. Using the normalized factor of normal tissues under the excitation source with 365 nm of the central wavelength and without the bandpass filter, the results revealed that the sensitivity was larger than 84%, the specificity was not smaller than over 76%, the accuracy was about 80%, and the area under curve of the receiver operating characteristic (ROC) was achieved at about 87%, respectively. The fact shows the LIAF spectroscopy has the possibilities of ex vivo diagnosis and noninvasive examinations for oral cancer.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Yung-Jhe Yan ; Ting-Wei Huang ; Nai-Lun Cheng ; Yao-Fang Hsieh ; Ming-Hsui Tsai, et al.
"Portable LED-induced autofluorescence spectroscopy for oral cancer diagnosis", J. Biomed. Opt. 22(4), 045007 (Apr 19, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.4.045007


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