Research Papers: General

Real-time temperature monitoring with fiber Bragg grating sensor during diffuser-assisted laser-induced interstitial thermotherapy

[+] Author Affiliations
Ngot Thi Pham, Seul Lee Lee

Pukyong National University, Interdisciplinary Program of Marine-Bio, Electrical and Mechanical Engineering, Busan, Republic of Korea

Suhyun Park

Chung-Ang University, School of Electrical and Electronics Engineering, Seoul, Republic of Korea

Yong Wook Lee

Pukyong National University, School of Electrical Engineering, Busan, Republic of Korea

Pukyong National University, Center for Marine-Integrated Biomedical Technology, Busan, Republic of Korea

Hyun Wook Kang

Pukyong National University, Center for Marine-Integrated Biomedical Technology, Busan, Republic of Korea

Pukyong National University, Department of Biomedical Engineering, Busan, Republic of Korea

J. Biomed. Opt. 22(4), 045008 (Apr 20, 2017). doi:10.1117/1.JBO.22.4.045008
History: Received December 6, 2016; Accepted March 28, 2017
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Abstract.  High-sensitivity temperature sensors have been used to validate real-time thermal responses in tissue during photothermal treatment. The objective of the current study was to evaluate the feasible application of a fiber Bragg grating (FBG) sensor for diffuser-assisted laser-induced interstitial thermotherapy (LITT) particularly to treat tubular tissue disease. A 600-μm core-diameter diffuser was employed to deliver 980-nm laser light for coagulation treatment. Both a thermocouple and a FBG were comparatively tested to evaluate temperature measurements in ex vivo liver tissue. The degree of tissue denaturation was estimated as a function of irradiation times and quantitatively compared with light distribution as well as temperature development. At the closer distance to a heat source, the thermocouple measured up to 41% higher maximum temperature than the FBG sensor did after 120-s irradiation (i.e., 98.7°C±6.1°C for FBG versus 131.0°C±5.1°C for thermocouple; p<0.001). Ex vivo porcine urethra tests confirmed the real-time temperature measurements of the FBG sensor as well as consistently circumferential tissue denaturation after 72-s irradiation (coagulation thickness=2.2±0.3  mm). The implementation of FBG can be a feasible sensing technique to instantaneously monitor the temperature developments during diffuser-assisted LITT for treatment of tubular tissue structure.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Ngot Thi Pham ; Seul Lee Lee ; Suhyun Park ; Yong Wook Lee and Hyun Wook Kang
"Real-time temperature monitoring with fiber Bragg grating sensor during diffuser-assisted laser-induced interstitial thermotherapy", J. Biomed. Opt. 22(4), 045008 (Apr 20, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.4.045008


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