Research Papers: Imaging

Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis

[+] Author Affiliations
Bernhard B. Zimmermann

Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts, United States

Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Cambridge, Massachusetts, United States

Bin Deng, Bhawana Singh, Juliette Selb, Amir Y. Sajjadi, David A. Boas, Stefan A. Carp

Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts, United States

Harvard Medical School, Department of Radiology, Boston, Massachusetts, United States

Mark Martino

Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts, United States

Qianqian Fang

Northeastern University, Department of Bioengineering, Boston, Massachusetts, United States

Jayne Cormier, Richard H. Moore

Massachusetts General Hospital, Breast Imaging Division, Department of Radiology, Boston, Massachusetts, United States

Daniel B. Kopans, Mansi A. Saksena

Harvard Medical School, Department of Radiology, Boston, Massachusetts, United States

Massachusetts General Hospital, Breast Imaging Division, Department of Radiology, Boston, Massachusetts, United States

J. Biomed. Opt. 22(4), 046008 (Apr 27, 2017). doi:10.1117/1.JBO.22.4.046008
History: Received December 15, 2016; Accepted April 7, 2017
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Abstract.  Diffuse optical tomography (DOT) is emerging as a noninvasive functional imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital breast tomosynthesis (DBT) is especially synergistic as DBT prior information can be used to enhance the DOT reconstruction. DOT, in turn, provides a functional information overlay onto the mammographic images, increasing sensitivity and specificity to cancer pathology. We describe a dynamic DOT apparatus designed for tight integration with commercial DBT scanners and providing a fast (up to 1 Hz) image acquisition rate to enable tracking hemodynamic changes induced by the mammographic breast compression. The system integrates 96 continuous-wave and 24 frequency-domain source locations as well as 32 continuous wave and 20 frequency-domain detection locations into low-profile plastic plates that can easily mate to the DBT compression paddle and x-ray detector cover, respectively. We demonstrate system performance using static and dynamic tissue-like phantoms as well as in vivo images acquired from the pool of patients recalled for breast biopsies at the Massachusetts General Hospital Breast Imaging Division.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Bernhard B. Zimmermann ; Bin Deng ; Bhawana Singh ; Mark Martino ; Juliette Selb, et al.
"Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis", J. Biomed. Opt. 22(4), 046008 (Apr 27, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.4.046008


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