Research Papers: Imaging

Colposcopic imaging using visible-light optical coherence tomography

[+] Author Affiliations
Lian Duan, Wenzhong Liu, Xiao Shu, Hao F. Zhang

Northwestern University, Department of Biomedical Engineering, Evanston, Illinois, United States

Michael D. McRaven, Thomas J. Hope

Northwestern University, Department of Cell and Molecular Biology, Chicago, Illinois, United States

Jianmin Hu

Northwestern University, Department of Biomedical Engineering, Evanston, Illinois, United States

Wuhan University of Technology, School of Information Engineering, Wuhan, Hubei, China

Cheng Sun

Northwestern University, Department of Mechanical Engineering, Evanston, Illinois, United States

Ronald S. Veazey

Tulane University, School of Medicine, Tulane National Primate Research Center, Covington, Louisiana, United States

J. Biomed. Opt. 22(5), 056003 (May 08, 2017). doi:10.1117/1.JBO.22.5.056003
History: Received January 11, 2017; Accepted April 17, 2017
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Abstract.  High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is capable of three-dimensional imaging over a 4.6×4.6-mm2 area using a pair of galvo scanners. Using this colposcopic vis-OCT with both probes, we acquired high-resolution images from whole isolated macaque vaginal samples and identified biopsy lesions.

Figures in this Article
© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Lian Duan ; Michael D. McRaven ; Wenzhong Liu ; Xiao Shu ; Jianmin Hu, et al.
"Colposcopic imaging using visible-light optical coherence tomography", J. Biomed. Opt. 22(5), 056003 (May 08, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.5.056003


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