Research Papers: General

Development and validation of a noncontact spectroscopic device for hemoglobin estimation at point-of-care

[+] Author Affiliations
Probir Kumar Sarkar, Nabarun Polley, Aniruddha Adhikari, Animesh Halder, Samir Kumar Pal

S. N. Bose National Centre for Basic Sciences, Department of Chemical, Biological, and Macromolecular Sciences, Salt Lake, Kolkata, India

Sanchari Pal, Prantar Chakrabarti

Nil Ratan Sircar Medical College and Hospital, Department of Clinical Haematology, Sealdah, Kolkata, West Bengal, India

Rajarshi Aich

Medical College and Hospital, Department of Cardiology, Central Avenue, Kolkata, West Bengal, India

Subhananda Chakrabarti

Indian Institute of Technology Bombay, Department of Electrical Engineering, Powai, Mumbai, Maharashtra, India

J. Biomed. Opt. 22(5), 055006 (May 16, 2017). doi:10.1117/1.JBO.22.5.055006
History: Received January 16, 2017; Accepted April 26, 2017
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Abstract.  Anemia severely and adversely affects human health and socioeconomic development. Measuring hemoglobin with the minimal involvement of human and financial resources has always been challenging. We describe a translational spectroscopic technique for noncontact hemoglobin measurement at low-resource point-of-care settings in human subjects, independent of their skin color, age, and sex, by measuring the optical spectrum of the blood flowing in the vascular bed of the bulbar conjunctiva. We developed software on the LabVIEW platform for automatic data acquisition and interpretation by nonexperts. The device is calibrated by comparing the differential absorbance of light of wavelength 576 and 600 nm with the clinical hemoglobin level of the subject. Our proposed method is consistent with the results obtained using the current gold standard, the automated hematology analyzer. The proposed noncontact optical device for hemoglobin estimation is highly efficient, inexpensive, feasible, and extremely useful in low-resource point-of-care settings. The device output correlates with the different degrees of anemia with absolute and trending accuracy similar to those of widely used invasive methods. Moreover, the device can instantaneously transmit the generated report to a medical expert through e-mail, text messaging, or mobile apps.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Probir Kumar Sarkar ; Sanchari Pal ; Nabarun Polley ; Rajarshi Aich ; Aniruddha Adhikari, et al.
"Development and validation of a noncontact spectroscopic device for hemoglobin estimation at point-of-care", J. Biomed. Opt. 22(5), 055006 (May 16, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.5.055006


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