Research Papers: General

Comparable change in stromal refractive index of cat and human corneas following blue-IRIS

[+] Author Affiliations
Kaitlin T. Wozniak, Sara M. Gearhart

University of Rochester, Institute of Optics, Rochester, New York, United States

Daniel E. Savage, Wayne H. Knox

University of Rochester, Institute of Optics, Rochester, New York, United States

University of Rochester, Center for Visual Science, Rochester, New York, United States

University of Rochester, Flaum Eye Institute, Rochester, New York, United States

Jonathan D. Ellis

University of Rochester, Institute of Optics, Rochester, New York, United States

University of Rochester, Department of Mechanical Engineering, Rochester, New York, United States

Krystel R. Huxlin

University of Rochester, Center for Visual Science, Rochester, New York, United States

University of Rochester, Flaum Eye Institute, Rochester, New York, United States

J. Biomed. Opt. 22(5), 055007 (May 24, 2017). doi:10.1117/1.JBO.22.5.055007
History: Received December 13, 2016; Accepted May 8, 2017
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Abstract.  Blue intratissue refractive index shaping (blue-IRIS) is a method with potential to correct ocular refraction noninvasively in humans. To date, blue-IRIS has only ever been applied to cat corneas and hydrogels. To test the comparability of refractive index change achievable in cat and human tissues, we used blue-IRIS to write identical phase gratings in ex vivo feline and human corneas. Femtosecond pulses (400 nm) were focused 300  μm below the epithelial surface of excised cat and human corneas and scanned to write phase gratings with lines 1  μm wide, spaced 5  μm apart, using a scan speed of 5  mm/s. Additional cat corneas were used to test writing at 3 and 7  mm/s in order to document speed dependence of the refractive index change magnitude. The first-order diffraction efficiency was immediately measured and used to calculate the refractive index change attained. Our data show that blue-IRIS induces comparable refractive index changes in feline and human corneas, an essential requirement for further developing its use as a clinical vision correction technique.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Kaitlin T. Wozniak ; Sara M. Gearhart ; Daniel E. Savage ; Jonathan D. Ellis ; Wayne H. Knox, et al.
"Comparable change in stromal refractive index of cat and human corneas following blue-IRIS", J. Biomed. Opt. 22(5), 055007 (May 24, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.5.055007


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