Special Section on Advanced Laser Technologies for Biophotonics

Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing

[+] Author Affiliations
Emil Sobol, Yulia Alexandrovskaya

Institute of Applied Physics of the Russian Academy of Sciences, Nizhny Novgorod, Russia

Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences, Institute of Photonic Technologies, Moscow, Russia

Olga Baum

Federal Scientific Research Centre “Crystallography and Photonics” of the Russian Academy of Sciences, Institute of Photonic Technologies, Moscow, Russia

Anatoly Shekhter

Sechenov First Medical University of Moscow, Institute of Regenerative Medicine, Moscow, Russia

Sebastian Wachsmann-Hogiu

University of California, Center for Biophotonics, Department of Pathology and Laboratory Medicine, Sacramento, California, United States

McGill University, Department of Bioengineering, Montreal, Canada

Alexander Shnirelman

Concordia University, Department of Mathematics and Statistics, Montreal, Canada

Ivan Sadovskyy, Valerii Vinokur

Argonne National Laboratory, Materials Science Division, Argonne, Illinois, United States

J. Biomed. Opt. 22(9), 091515 (May 31, 2017). doi:10.1117/1.JBO.22.9.091515
History: Received November 29, 2016; Accepted April 28, 2017
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Abstract.  Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-and-error approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Emil Sobol ; Olga Baum ; Anatoly Shekhter ; Sebastian Wachsmann-Hogiu ; Alexander Shnirelman, et al.
"Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing", J. Biomed. Opt. 22(9), 091515 (May 31, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.9.091515


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