JBO Letters

Delineating the anatomy of the ciliary body using hybrid optical and photoacoustic imaging

[+] Author Affiliations
George J. Tserevelakis, Stella Avtzi, Giannis Zacharakis

Foundation for Research and Technology Hellas, Institute of Electronic Structure and Laser, Heraklion, Crete, Greece

Miltiadis K. Tsilimbaris

University of Crete, School of Medicine, Laboratory of Vision and Optics, Heraklion, Crete, Greece

J. Biomed. Opt. 22(6), 060501 (Jun 14, 2017). doi:10.1117/1.JBO.22.6.060501
History: Received February 12, 2017; Accepted May 23, 2017
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Abstract.  We demonstrate the application of an extended field of view hybrid microscope, integrating distinct optical and photoacoustic (PA) contrast modes, for the precise three-dimensional anatomy delineation of the ciliary body/iris structures in healthy rabbit eyes ex vivo. The glutaraldehyde-induced autofluorescence and the intrinsic PA signals provided by each of the employed imaging modalities were characterized by a high spatial complementarity, offering thus rich morphological information regarding the pars plana and pars plicata ciliary body portions, the iris, as well as, the attached zonule fiber strands. The bimodal microscopy approach presented could find application on studies involving the ocular accommodation mechanism or pathological ciliary body conditions, as a powerful diagnostic technique contributing to the understanding of ocular physiology and function.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

George J. Tserevelakis ; Stella Avtzi ; Miltiadis K. Tsilimbaris and Giannis Zacharakis
"Delineating the anatomy of the ciliary body using hybrid optical and photoacoustic imaging", J. Biomed. Opt. 22(6), 060501 (Jun 14, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.6.060501


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