Research Papers: Imaging

Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence tomography

[+] Author Affiliations
Alex S. Huang, Vikas Chopra

Doheny Eye Institute, Los Angeles, California, United States

Doheny Eye Centers, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States

Akram Belghith, Linda M. Zangwill, Robert N. Weinreb

Shiley Eye Institute and Hamilton Glaucoma Center, Department of Ophthalmology University of California, San Diego, California, United States

Anna Dastiridou

Doheny Eye Centers, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States

J. Biomed. Opt. 22(6), 066010 (Jun 15, 2017). doi:10.1117/1.JBO.22.6.066010
History: Received January 6, 2017; Accepted May 30, 2017
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Abstract.  The purpose was to create a three-dimensional (3-D) model of circumferential aqueous humor outflow (AHO) in a living human eye with an automated detection algorithm for Schlemm’s canal (SC) and first-order collector channels (CC) applied to spectral-domain optical coherence tomography (SD-OCT). Anterior segment SD-OCT scans from a subject were acquired circumferentially around the limbus. A Bayesian Ridge method was used to approximate the location of the SC on infrared confocal laser scanning ophthalmoscopic images with a cross multiplication tool developed to initiate SC/CC detection automated through a fuzzy hidden Markov Chain approach. Automatic segmentation of SC and initial CC’s was manually confirmed by two masked graders. Outflow pathways detected by the segmentation algorithm were reconstructed into a 3-D representation of AHO. Overall, only <1% of images (5114 total B-scans) were ungradable. Automatic segmentation algorithm performed well with SC detection 98.3% of the time and <0.1% false positive detection compared to expert grader consensus. CC was detected 84.2% of the time with 1.4% false positive detection. 3-D representation of AHO pathways demonstrated variably thicker and thinner SC with some clear CC roots. Circumferential (360 deg), automated, and validated AHO detection of angle structures in the living human eye with reconstruction was possible.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Alex S. Huang ; Akram Belghith ; Anna Dastiridou ; Vikas Chopra ; Linda M. Zangwill, et al.
"Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence tomography", J. Biomed. Opt. 22(6), 066010 (Jun 15, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.6.066010


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