Research Papers: Imaging

Gadolinium/terbium hybrid macromolecular complexes for bimodal imaging of atherothrombosis

[+] Author Affiliations
Nguyễn Trọng Nghĩa

University Paris 13, Institut Galilée, University Sorbonne Paris-Cité, Laser Physics Laboratory, CNRS UMR 7538, Villetaneuse, France

University Paris 13, Institut Galilée, University Sorbonne Paris-Cité, Laboratory for Vascular Translational Science, INSERM U1148, Villetaneuse, France

Eric Tinet, Dominique Ettori, Jean-Michel Tualle

University Paris 13, Institut Galilée, University Sorbonne Paris-Cité, Laser Physics Laboratory, CNRS UMR 7538, Villetaneuse, France

Anne Beilvert, Graciela Pavon-Djavid, Murielle Maire, Frédéric Chaubet

University Paris 13, Institut Galilée, University Sorbonne Paris-Cité, Laboratory for Vascular Translational Science, INSERM U1148, Villetaneuse, France

Phalla Ou

University Paris-Diderot, CHU X. Bichat, University Sorbonne Paris-Cité, Laboratory for Vascular Translational Science, INSERM U1148, Paris, France

Hôpital Bichat, AP-HP, Paris, France

J. Biomed. Opt. 22(7), 076004 (Jul 11, 2017). doi:10.1117/1.JBO.22.7.076004
History: Received January 24, 2017; Accepted June 15, 2017
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Abstract.  We developed a fluorescence imaging microscope system intended for the localization within artery slices of a gadolinium-based macromolecular biospecific magnetic resonance (MR) contrast agent used for the visualization of atherothrombosis. As the contrast agent is not initially fluorescent, we substitute some gadolinium ions for terbium ions to make them fluorescent while preserving their chemical characteristics. A long fluorescence emission time constant enables us to have a suitable signal-to-noise ratio, despite a low intensity, using pulsed illumination and time-gated imaging. Images of rat arteries show that the contrast agent is indeed localized on the specific regions of the tissues. We currently have a tool that allows us to understand and optimize the MR contrast agent.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Nguyễn Trọng Nghĩa ; Eric Tinet ; Dominique Ettori ; Anne Beilvert ; Graciela Pavon-Djavid, et al.
"Gadolinium/terbium hybrid macromolecular complexes for bimodal imaging of atherothrombosis", J. Biomed. Opt. 22(7), 076004 (Jul 11, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.7.076004


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