Special Section on Translational Biophotonics

Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy

[+] Author Affiliations
Songhyun Lee, Hyeryun Jeong, Myeongsu Seong

Gwangju Institute of Science and Technology, Department of Biomedical Science and Engineering, Gwangju, Republic of Korea

Jae Gwan Kim

Gwangju Institute of Science and Technology, Department of Biomedical Science and Engineering, Gwangju, Republic of Korea

Gwangju Institute of Science and Technology, School of Electrical Engineering and Computer Science, Gwangju, Republic of Korea

J. Biomed. Opt. 22(12), 121603 (Jul 12, 2017). doi:10.1117/1.JBO.22.12.121603
History: Received March 2, 2017; Accepted May 31, 2017
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Abstract.  Breast cancer is one of the most common cancers in females. To monitor chemotherapeutic efficacy for breast cancer, medical imaging systems such as x-ray mammography, computed tomography, magnetic resonance imaging, and ultrasound imaging have been used. Currently, it can take up to 3 to 6 weeks to see the tumor response from chemotherapy by monitoring tumor volume changes. We used near-infrared spectroscopy (NIRS) to predict breast cancer treatment efficacy earlier than tumor volume changes by monitoring tumor vascular reactivity during inhalational gas interventions. The results show that the amplitude of oxy-hemoglobin changes (vascular reactivity) during hyperoxic gas inhalation is well correlated with tumor growth and responded one day earlier than tumor volume changes after chemotherapy. These results may imply that NIRS with respiratory challenges can be useful in early detection of tumor and in the prediction of tumor response to chemotherapy.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Songhyun Lee ; Hyeryun Jeong ; Myeongsu Seong and Jae Gwan Kim
"Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy", J. Biomed. Opt. 22(12), 121603 (Jul 12, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.12.121603


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