JBO Letters

Analysis of skin blood microflow oscillations in patients with rheumatic diseases

[+] Author Affiliations
Irina Mizeva

Institute of Continuous Media Mechanics, Perm, Russia

Irina Makovik, Andrey Dunaev

Orel State University named after I.S. Turgenev, Orel, Russia

Alexander Krupatkin

Priorov Central Scientific Research Institute of Traumatology and Orthopedics, Moscow, Russia

Igor Meglinski

University of Oulu, Opto-Electronics and Measurement Techniques, Oulu, Finland

Institute of Biology, Irkutsk State University, Irkutsk, Russia

ITMO University, St. Petersburg, Russia

Tomsk State University, Interdisciplinary Laboratory of Biophotonics, Tomsk, Russia

J. Biomed. Opt. 22(7), 070501 (Jul 13, 2017). doi:10.1117/1.JBO.22.7.070501
History: Received May 25, 2017; Accepted June 21, 2017
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Abstract.  Laser Doppler flowmetry (LDF) has been applied for the assessment of variation in blood microflows in patients with rheumatic diseases and healthy volunteers. Oscillations of peripheral blood microcirculation observed by LDF have been analyzed utilizing a wavelet transform. A higher amplitude of blood microflow oscillations has been observed in a high frequency band (over 0.1 Hz) in patients with rheumatic diseases. Oscillations in the high frequency band decreased in healthy volunteers in response to the cold pressor test, whereas lower frequency pulsations prevailed in patients with rheumatic diseases. A higher perfusion rate at normal conditions was observed in patients, and a weaker response to cold stimulation was observed in healthy volunteers. Analysis of blood microflow oscillations has a high potential for evaluation of mechanisms of blood flow regulation and diagnosis of vascular abnormalities associated with rheumatic diseases.

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© 2017 Society of Photo-Optical Instrumentation Engineers

Citation

Irina Mizeva ; Irina Makovik ; Andrey Dunaev ; Alexander Krupatkin and Igor Meglinski
"Analysis of skin blood microflow oscillations in patients with rheumatic diseases", J. Biomed. Opt. 22(7), 070501 (Jul 13, 2017). ; http://dx.doi.org/10.1117/1.JBO.22.7.070501


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