Characterizing subepithelial remodeling in eosinophilic esophagitis with PS-μOCT

Conor J. Sheil; Andreas Wartak; Joseph A. Gardecki; Abigail L Gregg; Guillermo J. Tearney

doi:10.1117/12.2609948

7 March 2022 Characterizing subepithelial remodeling in eosinophilic esophagitis with PS-μOCT

Conor J. Sheil, Andreas Wartak, Joseph A. Gardecki, Abigail L Gregg, Guillermo J. Tearney

Proceedings Volume PC11937, Endoscopic Microscopy XVII; PC119370J (2022) https://doi.org/10.1117/12.2609948
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Eosiophilic esophagitis (EoE) is an inflammatory disease of the esophagus, with long-term EoE causing fibrotic and hypertrophic restructuring of the sub-epithelial wall. We have developed a polarization-sensitive micro-optical coherence tomography (PS-µOCT) imaging device for its characterization. This device was used to quantify collagen at 15 sites on each of 5 swine esophagi, with results compared to histology. A linear mixed model with random intercept showed significant agreement between OCT and histology (slope = 0.41, 95% CI [0.22, 0.60], t(67) = 4.30, p = 5.8 x 10-5). This validates our technology and will allow longitudinal assessment of patient response to drug and diet, without endoscopic biopsy.

Conference Presentation

Citation Download Citation

Conor J. Sheil, Andreas Wartak, Joseph A. Gardecki, Abigail L Gregg, and Guillermo J. Tearney "Characterizing subepithelial remodeling in eosinophilic esophagitis with PS-μOCT", Proc. SPIE PC11937, Endoscopic Microscopy XVII, PC119370J (7 March 2022); https://doi.org/10.1117/12.2609948

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