Multimodal vibrational imaging based on mid-infrared photothermal microscopy

Ryo Kato; Taka-aki Yano; Takuo Tanaka

doi:10.1117/12.2607443

2 March 2022 Multimodal vibrational imaging based on mid-infrared photothermal microscopy

Ryo Kato, Taka-aki Yano, Takuo Tanaka

Proceedings Volume PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022; PC119730I (2022) https://doi.org/10.1117/12.2607443
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Vibrational imaging based on mid-infrared photothermal (MIP) microscopy with the sub-micrometer spatial resolution is an indispensable analytical tool for a wide range of fields, such as polymer and medical science. In this talk, we will report multimodal imaging of polymer blends and biomolecules combining a MIP imaging with other optical microscopic techniques such as Raman or fluorescence imaging. Since Raman scattering exhibits complementary information of molecular vibrations and fluorescence imaging helps to understand biological dynamics by visualizing the distribution of biomarkers, our demonstration of multimodal imaging offers accurate and detailed characterization of molecular structures and functions of various samples.

Conference Presentation

Citation Download Citation

Ryo Kato, Taka-aki Yano, and Takuo Tanaka "Multimodal vibrational imaging based on mid-infrared photothermal microscopy", Proc. SPIE PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022, PC119730I (2 March 2022); https://doi.org/10.1117/12.2607443

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