Dual-resolution, catheter-based probe for visualization of angular-diverse scattering contrast of esophagus in vivo with optical coherence tomography

Taylor M. Cannon; Milen Shishkov; Ginger J. Schmidt; Martin Villiger; Brett E. Bouma; Néstor Uribe-Patarroyo

doi:10.1117/12.2650387

17 March 2023 Dual-resolution, catheter-based probe for visualization of angular-diverse scattering contrast of esophagus in vivo with optical coherence tomography

Taylor M. Cannon, Milen Shishkov, Ginger J. Schmidt, Martin Villiger, Brett E. Bouma, Néstor Uribe-Patarroyo

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Proceedings Volume PC12356, Endoscopic Microscopy XVIII; PC1235609 (2023) https://doi.org/10.1117/12.2650387
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Improving the sensitivity of endoscopic optical coherence tomography (OCT) to pre-cancerous esophageal lesions stands to improve patient outcomes. Although nuclei-level features relevant to dysplasia diagnoses are below conventional OCT systems’ resolution, tissue scattering properties report local particle size and concentration, indirectly accessing nuclei diameter and nuclear-cytoplasmic ratio (NCR). Recently, we have shown that acquiring co-registered images of a sample at different numerical aperture (NA) enhances scattering property measurements through angular diversity. We present preliminary results for a custom-designed, catheter-based, dual-NA endoscopic probe demonstrating improved characterization of phantoms and tissue with histological validation, and potential utility for more sensitive dysplasia diagnoses.

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Taylor M. Cannon, Milen Shishkov, Ginger J. Schmidt, Martin Villiger, Brett E. Bouma, and Néstor Uribe-Patarroyo "Dual-resolution, catheter-based probe for visualization of angular-diverse scattering contrast of esophagus in vivo with optical coherence tomography", Proc. SPIE PC12356, Endoscopic Microscopy XVIII, PC1235609 (17 March 2023); https://doi.org/10.1117/12.2650387

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KEYWORDS

Scattering

Optical coherence tomography

In vivo imaging

Visualization

Esophagus

Scatter measurement

Tissues

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